6555-61-9Relevant academic research and scientific papers
Enantioconvergent alkylation of ketones with racemic secondary alcohols: Via hydrogen borrowing catalysis
Cheang, Daniella M. J.,Armstrong, Roly J.,Akhtar, Wasim M.,Donohoe, Timothy J.
supporting information, p. 3543 - 3546 (2020/04/03)
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.
