65555-88-6Relevant academic research and scientific papers
Chiral azo compounds: Enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter
Dietz, Friedrich R.,Prechter, Agnes,Gr?ger, Harald,Heinrich, Markus R.
, p. 655 - 657 (2011/03/21)
Taking advantage of radical carboaminations producing azo compounds, a new chemo-enzymatic approach to enantiomerically enriched azo alcohols, β-amino alcohols and non-natural (aromatic) amino acids with a quaternary stereocenter is reported.
Microbial synthesis of chiral intermediates for β-3-receptor agonists
Patel,Banerjee,Chu,Brozozowski,Nanduri,Szarka
, p. 1473 - 1482 (2007/10/03)
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of β-3-receptor agonists. These include: (i) the microbial reduction of 4-benzyloxy-3-methanesulfonylamino-2′-bromoacetophenone 1 to the corresponding (R)-alcohol 2 by
Synthesis of Optically Pure α-Alkylated α-Amino Acids and a Single-Step Method for Enatiomeric Excess Determination
Kruizinga, Wim H.,Bolster, John,Kellogg, Richard M.,Kamphuis, Johan,Boesten, Wilhelmus H. J.,et al.
, p. 1826 - 1827 (2007/10/02)
A method for the enzymatic resolution of the amides of some racemic α-alkylated amino acids is described as well as a method involving derivatization with (S)-2-chloropropionyl chloride followed by 1H NMR analysis to establish the enantiomeric excesses of the free amino acids.
ENZYME CATALYSED HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIESTERS, SYNTHESIS OF OPTICALLY PURE (S)-α-METHYLPHENYLALANINE, (S)-α-METHYLTYROSINE AND (S)-α-METHYL-3,4-DIHYDROXYPHENYLALANINE
Bjoerkling, Fredrik,Boutelje, John,Gatenbeck, Sten,Hult, Karl,Norin, Torbjoern
, p. 4957 - 4958 (2007/10/02)
Pig liver esterase and α-chymotrypsin catalysed hydrolysis of the meso-diesters 1, 2 and 3 gave the corresponding monoesters which then could be transformed into enantiomerically pure (S)-α-methylphenylalanine, (S)-α-methyltyrosine and (S)-α-methyl-3,4-dihydroxyphenylalanine.
Chirally substituted 2-imidazolin-5-ones
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, (2008/06/13)
Chirally substituted 2-imidazolin-5-ones and their use as intermediates for the preparation of optically active aminoacids, especially of optically active α-substituted aminoacids.
