O,alpha-dimethyl-L-tyrosine

Base Information

Chemical Name:O,alpha-dimethyl-L-tyrosine
CAS No.:65555-88-6
Molecular Formula:C₁₁H₁₅NO₃
Molecular Weight:209.245
Hs Code.:
European Community (EC) Number:850-653-8
UNII:N51CEY7JMT
Nikkaji Number:J135.044G

Synonyms:65555-88-6;O,alpha-dimethyl-L-tyrosine;(2S)-2-Amino-3-(4-methoxyphenyl)-2-methylpropanoic acid;(S)-2-Amino-3-(4-methoxyphenyl)-2-methylpropanoic acid;N51CEY7JMT;4-Methoxy-a-methyl-L-phenylalanine;L-Tyrosine, O,alpha-dimethyl-;UNII-N51CEY7JMT;Methyldopa specified impurity B [EP];starbld0001574;O-METHYL METYROSINE;SCHEMBL2033365;O,.ALPHA.-DIMETHYL-L-TYROSINE;L-TYROSINE, O,.ALPHA.-DIMETHYL-;METHYLDOPA IMPURITY B [EP IMPURITY];CS-0088876;EN300-7563364;Q27284564;(S)-2-Amino-3-(4-methoxy-phenyl)-2-methyl-propionic acid

Suppliers and Price of O,alpha-dimethyl-L-tyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of O,alpha-dimethyl-L-tyrosine

Chemical Property:

XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:209.10519334
Heavy Atom Count:15
Complexity:224

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC1=CC=C(C=C1)OC)(C(=O)O)N
Isomeric SMILES:C[C@](CC1=CC=C(C=C1)OC)(C(=O)O)N

Technology Process of O,alpha-dimethyl-L-tyrosine

There total 9 articles about O,alpha-dimethyl-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65555-88-6
α-methyl-β-p-methoxyphenyl-alanine

: 618-36-0
rac-methylbenzylamine

Guidance literature:

Reference yield:

: 927196-12-1
acetic acid 3-(4-methoxyphenyl)-2-(4-methoxyphenylazo)-2-methylpropyl ester

: 65555-88-6
α-methyl-β-p-methoxyphenyl-alanine

: 132616-92-3
O,α-dimethyl-D-tyrosine

Guidance literature:: acetic acid 3-(4-methoxyphenyl)-2-(4-methoxyphenylazo)-2-methylpropyl ester; In tert-butyl methyl ether; at 40 ℃; for 168h; pH=7.5; Enzymatic reaction;

With hydrogenchloride; water; zinc; In methanol; at 20 ℃; for 4h;

With sodium periodate; sodium dichromate; sulfuric acid; In water; at 20 ℃; for 20h; enantioselective reaction;
DOI:10.1016/j.tetlet.2010.11.137

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 65555-88-6
α-methyl-β-p-methoxyphenyl-alanine

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 0 - 25 °C

2: α-chymotrypsin / dimethylsulfoxide; H2O / 22 - 25 °C / potassium phosphate ( pH 7.0); with pig liver esterase the reaction rate is higher but the e.e. is lower

3: 1.) acyl azide formation, 2.) Curtius rearrangement

With sodium hydride; α-chymotrypsin; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)94996-7