65562-49-4

Usage

InChI:InChI=1/C10H5Cl2NOS2/c11-6-2-1-3-7(12)5(6)4-8-9(14)13-10(15)16-8/h1-4H,(H,13,14,15)/b8-4+

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 65562-26-7 5-(2,6-dichloro-benzylidene)-3-(tetra-O-acetyl-β-D-glucopyranosyl)-2-thioxo-thiazolidin-4-one 
• 846038-18-4 1-benzo[b]thiophen-4-ylpiperazine hydrochloride 
• 1420987-86-5 C₂₀H₁₈N₂S₂ 
• 23967-57-9 4-chloro-2-benzo[b]thiophenecarboxylic acid 
• 1420987-77-4 (Z)-3-(2,6-dichlorophenyl)-2-mercapto-2-propenoic acid 

Relevant academic research and scientific papers

METHOD FOR PRODUCING BENZO[B]THIOPHENE COMPOUND

The present invention provides a method for producing a compound of Formula (4): wherein R1 is a hydrogen atom etc. by reacting a compound of Formula (2): wherein X1 is a leaving group, with a compound of Formula (3): wherein R1 is as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation.

N glucopyranosyl 5 aralkylidenerhodanines: Synthesis and antibacterial and antiviral activities

A series of N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-aralkylidenerhodanines was synthesized, and the acetyl groups were removed to give N-β-D-glucopyranosyl-5-aralkylidenerhodanines without cleavage of the rhodanine ring by means of acid hydrolysis. Alkaline hydrolysis with ammonia in methanol resulted in cleavage to N-glucosylthiourea, providing evidence for N-glycoside formation. A number of the rhodanine derivatives, especially those with nitro or chloro groups in the aromatic ring, showed antibacterial activity. N-β-D-Glucopyranosyl-5-(4-nitrobenzylidene)rhodanine showed antiviral activity by inhibition of viral RNA synthesis. Some effect on blood sugar levels also was observed with several rhodanines.