65563-75-9

Basic information

• Product Name: 2,5a-dimethyl-9-methylideneoctahydro-2H-oxireno[4,4a]naphtho[2,3-b]furan-8(9H)-one
• Synonyms: Naphtho[2,3-b]furan-2-one, perhydro-4,4a-epoxy-3-methylene-5,8a-dimethyl-
• CAS NO: 65563-75-9
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.3175
• Mol File: 65563-75-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 398.7°C at 760 mmHg
• Flash Point: 168.5°C
• Density: 1.18g/cm³
• Vapor Pressure: 1.44E-06mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 2,5a-dimethyl-9-methylideneoctahydro-2H-oxireno[4,4a]naphtho[2,3-b]furan-8(9H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5a-dimethyl-9-methylideneoctahydro-2H-oxireno[4,4a]naphtho[2,3-b]furan-8(9H)-one(65563-75-9)
• EPA Substance Registry System: 2,5a-dimethyl-9-methylideneoctahydro-2H-oxireno[4,4a]naphtho[2,3-b]furan-8(9H)-one(65563-75-9)

Safety Data

• Hazardous Substances Data: 65563-75-9(Hazardous Substances Data)

Usage

Molecular structure

2,5a-dimethyl-9-methylideneoctahydro-2H-oxireno[4,4a]naphtho[2,3-b]furan-8(9H)-one has a complex molecular structure, which includes a three-membered cyclic ether ring (oxirene) and a naphtho-furan ring system.

Type of compound

It is a type of oxirene, which is a class of organic compounds containing a three-membered cyclic ether ring.

Presence of multiple groups

The compound contains multiple methyl (CH3) and methylidene (CH2) groups, which contribute to its chemical and physical properties.

Naphtho-furan ring system

The presence of a naphtho-furan ring system in the compound adds to its complexity and potential applications.

Unique chemical and physical properties

Due to the presence of various groups and ring systems, the compound exhibits unique chemical and physical properties that may make it useful in various applications.

Potential applications

The compound may be useful in fields such as pharmaceutical or material science research, owing to its unique properties.

Complex structure analysis

The compound's complex structure requires careful handling and detailed analysis to fully understand its behavior and potential uses.

Upstream product

• 546-43-0 alantolactone 

Relevant articles and documents

Sesquiterpene lactone nitrogen methyl piperazine derivative and salt thereof, and application thereof in medicine preparation

The invention relates to sesquiterpene lactone nitrogen methyl piperazine derivatives and pharmaceutically acceptable salts thereof, and applications thereof in medicine preparation. The invention concretely relates to compounds represented by formulas (I), (II), (III) and (IV), and pharmaceutically acceptable salts thereof, as well as the applications of the compounds shown in formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts and compositions thereof for preparing anti-cancer or auxiliary anti-cancer drugs.

Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-β1 pathway

In this study, anti-IPF lead compounds 42 and 44, derived from natural sesquiterpene lactones Isoalantolactone and alantolactone, were discovered by screening from a high-throughput TGF-β1 reporter luciferase assay. Notably, they could reduce the myofibroblast activation and extracellular matrix deposition both in vitro and in vivo. Additionally, compounds 42 and 44 could significantly attenuate bleomycin-induced pulmonary fibrosis in mice. Further validation of pharmacokinetics study and toxicity evaluation indicated that compound 44 might be a promising anti-IPF drug candidate.

Application of alantolactone derivative and salt thereof in preparing drug for treating thyroiditis

The invention relates to application of an alantolactone derivative and salt thereof in preparing a drug for treating thyroiditis, and provides application of the alantolactone derivative as the formula (I-II) or the formula (I-III) and the salt thereof in preparing the drug for treating thyroiditis. Acid for forming the salt is inorganic or organic acid, the inorganic acid is selected from hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid, boracic acid, seleninic acid, phosphomolybdic acid, phosphorous acid and sulphurous acid, and the organic acid is selected from citric acid, maleic acid, D-malic acid, L-malic acid, DL-malic acid, L-lactic acid, D-lactic acid, DL-lactic acid, oxalic acid, methanesulfonic acid, pentanoic acid, oleic acid, lauric acid, p-methylbenzene sulfonic acid, 1-naphthalene sulfonic acid, 2-naphthalene sulfonic acid, phthalic acid, tartaric acid, malonic acid, succinic acid, fumaric acid, glycollic acid, mercaptan acid, glycine, sarcosine, sulfonic acid, nicotinic acid, methylpyridine, isonicotinic acid, benzoic acid and substituted benzoic acid.