65565-12-0

Upstream product

• 58084-06-3 3-(3-bromophenyl)-1-phenylprop-2-yn-1-one 
• 98-85-1 1-Phenylethanol 
• 15852-73-0 (3-Bromophenyl)methanol 
• 98-86-2 acetophenone 
• 29816-74-8 (E)-3-(3-bromophenyl)-1-phenyl-2-propen-1-one 
• 937375-28-5 3-(3-bromophenyl)-N-methoxy-N-methylpropanamide 
• 100-58-3 phenylmagnesium bromide 
• 29816-74-8 3-(3-bromophenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 937375-29-6 5-[2-(3-bromophenyl)ethyl]-5-phenylimidazolidine-2,4-dione 

Relevant academic research and scientific papers

Electrochemical-Induced Hydrogenation of Electron-Deficient Internal Olefins and Alkynes with CH3OH as Hydrogen Donor

Efficient hydrogenation of electron-deficient internal olefins and alkynes access to saturate ketone with CH3OH as a single hydrogen donor under electrochemical conditions has been successfully developed. This hydrogenation strategy can be used to convert electron-deficient internal olefins and alkynes to saturate ketone under electrochemical conditions with exogenous-reductant and a metal catalyst. Mechanistic studies reveal that radical hydrogenation was involved in this transformation. Notably, various electron-deficient internal olefins and alkynes could be tolerated in such an electrochemical hydrogenation synthetic strategy and can be easily scaled up with good efficiency. (Figure presented.).

Iridium Complexes as Efficient Catalysts for Construction of α-Substituted Ketones via Hydrogen Borrowing of Alcohols in Water

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of α-alkylated ketones in high yield (86 %–95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of α-alkylated ketones.

Lithium tert-butoxide mediated α-alkylation of ketones with primary alcohols under transition-metal-free conditions

LiOtBu was found to efficiently promote the α-alkylation reaction of ketones with primary alcohols, without the addition of any transition metal catalyst.

Aldehyde-catalyzed transition metal-free dehydrative β-alkylation of methyl carbinols with alcohols

Different to the borrowing hydrogen strategy in which alcohols were activated by transition metal-catalyzed anaerobic dehydrogenation, the direct addition of aldehydes was found to be an effective but simpler way of alcohol activation that can lead to efficient and green aldehyde-catalyzed transition metal-free dehydrative C-alkylation of methyl carbinols with alcohols. Mechanistic studies revealed that the reaction proceeds via in situ formation of ketones by Oppenauer oxidation of the methyl carbinols by external aldehydes, aldol condensation, and Meerwein-Ponndorf-Verley (MPV)-type reduction of α,β-unsatutated ketones by substrate alcohols, affording the useful long chain alcohols and generating aldehydes and ketones as the by-products that will be recovered in the next condensation to finish the catalytic cycle. Copyright

Selective 1,4-reduction of chalcones with Zn/NH4Cl/C 2H5OH/H2O

In this paper, the Zn/NH4Cl/C2H5OH/H 2O system was applied for the selective 1,4-reduction of chalcones undermild conditions with high selectivity. Themerit lies in inexpensive reagent, simple operation and envi

NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA

This invention relates to novel compounds having the structural formula I below and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Di