65568-95-8Relevant academic research and scientific papers
Cloxacepride and related compounds: A new series of orally active antiallergic compounds
Metz,Pindell,Chen
, p. 1065 - 1070 (2007/10/02)
4-[(p-Chlorophenoxy)acetyllamino]-5-chloro-2-methoxy-N-[2-(diethylamino)ethyl]benzamide (cloxacepride) exhibited substantial oral antiallergic potential in a reaginic PCA test in rats over a wide range of antigenic challenge times. Available reference compounds with oral activity, such as doxantrazole and 7-(2-hydroxyethoxy)-9-oxo-xanthene-2-carboxylic acid (AH 7725, 4) were active only when administered 15 min before challenge: 4, in particular, was not consistent in effect. Oral ED50 values for cloxacepride of 46-49 mg/kg were comparable to that of theophylline and to an intravenous injection of 2 mg/kg of disodium chromoglycate (DSCG) followed by immediate challenge. Following oral ED50 doses, 1 showed slower onset and longer duration of action than theophylline. The absence of inhibition of systemic anaphylaxis and of antihistaminic activity suggests specific effect for reaginic antigen antibody reactions. Structure-activity relationships of various chemical modifications were investigated and discussed in terms of essential substituents.
Anti-inflammatory N-acyl substituted benzamides
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, (2008/06/13)
There are disclosed N-acyl substituted benzamides of the general formula: STR1 wherein: X is carbon or nitrogen; R1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy; Y is the radical --O--, --NH-- or --S--; Z is an alkyl
