65576-63-8Relevant academic research and scientific papers
One-pot synthesis of thiazolo[3,2-α]pyridine derivatives catalysed by ionic liquids
Chen, Hai-Liang,Guo, Hong-Yun
experimental part, p. 162 - 165 (2012/09/22)
A green method for the synthesis of thiazolo[3,2-α]pyridine derivatives via the coupling of malononitrile, an aryl aldehyde and methyl thioglycolate in an ionic liquid has been developed. The advantages of this protocol are that it is non-toxic, no by-products are formed, short reaction times are required and high yields are obtained. Thiazolo [3,2-a]pyridines have important biological and medical applications.
THE REACTION OF THIOGLYCOLIC ACID WITH α,β-UNSATURATED NITRILES: A NEW ROUTE FOR THE SYNTHESIS OF THIAZOLOPYRIDINES
Elnagdi, Mohamed Hilmy,Elmoghayar, Mohamed Rifat Hamza,Elghandour, Ahmed Hafez Hussein,Sadek, Kamal Usef
, p. 745 - 751 (2007/10/02)
The reaction of cinnamonitriles with thioglycolic acid in the presence of a basic catalyst affords thiazolopyridine derivatives.
Activated Nitriles in Heterocyclic Synthesis: The Reaction of Substituted Cinnamonitriles with 2-Functionally Substituted Methyl-2-thiazolin-4-one Derivatives
Sadek, Kamal Usef,Hafez, Ebtisam Abdel Aziz,Mourad, Abo-Elfetouh E.,Elnagdi, Mohamed Hilmy
, p. 824 - 828 (2007/10/02)
A variety of thiazolopyridine and 3-(2-thiazolin-2-yl)pyridine derivatives were synthesised via the reaction of arylsubstituted cinnamonitrile derivatives with 2-functionally substituted 2-thiazolin-4-one derivatives.Thiazolopyridines were a
