65578-36-1

Basic information

• Product Name: (E)-ethyl 3-(MethyliMino)butanoate
• Synonyms: (E)-ethyl 3-(MethyliMino)butanoate
• CAS NO: 65578-36-1
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Mol File: 65578-36-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-ethyl 3-(MethyliMino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 3-(MethyliMino)butanoate(65578-36-1)
• EPA Substance Registry System: (E)-ethyl 3-(MethyliMino)butanoate(65578-36-1)

Safety Data

• Hazardous Substances Data: 65578-36-1(Hazardous Substances Data)

Usage

General Description

(E)-Ethyl 3-(MethyliMino)butanoate is a chemical compound that belongs to the ester class. It is commonly used in the synthesis of various substances in the pharmaceutical and fragrance industries. Its molecular structure consists of a butanoic acid derivative with an ethyl group on one end and a methylamino group on the other, giving it a fruity and floral fragrance. It is also known to exhibit antimicrobial properties and is used as a flavoring agent in food and beverages. Additionally, it is a common ingredient in perfumes, lotions, and other personal care products due to its pleasant scent.

Upstream product

• 64-17-5 ethanol 
• 85093-96-5 2,3-dimethylisoxazolium iodide 
• 141-97-9 ethyl acetoacetate 
• 74-89-5 methylamine 

Downstream Products

• 40963-98-2 ethyl 5-methoxy-1,2-dimethyl-1H-indole-3-carboxylate 
• 52535-61-2 ethyl 1,2-dimethyl-5-methoxy-4-nitroindole-3-carboxylate 
• 52535-65-6 ethyl 4-amino-1,2-dimethyl-5-methoxyindole-3-carboxylate 
• 930285-79-3 carbonic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester 4-nitro-phenyl ester 
• 15574-49-9 mecarbinate 
• 40945-79-7 1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester 
• 131707-24-9 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester 
• 110543-98-1 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester 
• 109964-12-7 1,2-dimethyl-3-ethoxycarbonyl-5-oxybenzindole 

Relevant articles and documents

Preparation method of arbidol intermediate

The invention discloses a preparation method of an arbidol intermediate. Ethyl acetoacetate, monomethylamine and p-benzoquinone used as initial raw materials undergo methylation, cyclization, acetylation, bromination and benzene vulcanization to prepare the target compound ethyl 5-hydroxy-6-bromo-2-phenylthiomethyl-1-methylindole-3-carboxylate. The preparation method of the arbidol intermediate issimple and convenient to operate, cheap and easily available in raw materials, high in yield, low in cost, good in quality, environment-friendly, mild in reaction condition, high in safety productioncoefficient and suitable for large-scale industrial production.

Ring Cleavage Reactions of 3- and 5-Non-substituted Isoxazoles

5-Methylisoxazoles with electron-accepting groups at C-4 (Ia-c) and 2,3-dimethylisoxazolium iodide (II) undergo ring cleavage when treated with organic bases.The nature of the open chain products which were obtained (stable enolates, β-diketones, esters) depends on the group at C-4 and the strength of the base.In some of these processes aromatic aldehydes were used in order to determine the competition between the condensation and the cleavage reaction.The mechanism of the nucleophilic ring cleavage of II is also shown.