6558-64-1

Usage

Uses

Used in Environmental and Public Health Research:
5-Methyl-imidazo[1,5-a]pyridine is used as a biomarker in environmental and public health research to study the effects of cigarette smoke exposure. Its presence in cigarette smoke serves as an indicator of the potential carcinogenic risks associated with tobacco use.
Used in Toxicology Studies:
MIP is utilized in toxicology studies to investigate the mutagenic and genotoxic effects of cigarette smoke on cells. Understanding the mechanisms by which MIP induces cellular damage can help in developing strategies to mitigate the harmful effects of tobacco smoke.
Used in Regulatory Compliance and Air Quality Monitoring:
5-Methyl-imidazo[1,5-a]pyridine is used as a reference compound in regulatory compliance and air quality monitoring to assess the presence of hazardous air pollutants. Its identification and quantification in environmental samples can aid in enforcing regulations and ensuring public health safety.
Used in Cancer Research:
MIP is employed in cancer research as a model compound to study the molecular mechanisms underlying the development of lung cancer. Investigating the role of MIP in tumorigenesis can provide insights into the pathogenesis of smoking-related cancers and contribute to the development of targeted therapies.
Used in Chemical Education and Awareness Programs:
5-Methyl-imidazo[1,5-a]pyridine serves as a teaching tool in chemical education and awareness programs to illustrate the harmful effects of cigarette smoke and the importance of tobacco control measures. Educating the public about the presence of potent carcinogens like MIP in cigarette smoke can promote smoking cessation and reduce tobacco-related health risks.

InChI:InChI=1/C8H8N2/c1-7-3-2-4-8-5-9-6-10(7)8/h2-6H,1H3

Upstream product

• 54384-88-2 N-((6-methylpyridin-2-yl)methyl)formamide 
• 6627-60-7 2-aminomethyl-6-methylpyridine 
• 1620-75-3 2-Cyano-6-methylpyridine 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 76259-00-2 imidazo[1,5-a]pyridine-3-thiol 
• 76266-05-2 3-ethylthio-5-methylimidazo<1,5-a>pyridine 
• 76266-04-1 3-ethylsulfanyl-imidazo[1,5-a]pyridine 

Downstream Products

• 85691-74-3 pirmagrel 
• 849797-85-9 2-benzyl-5-methylimidazo[1,5-a]pyridine-3-ylidene 

Relevant academic research and scientific papers

Preparation method of N- phenyl-2-aminopyrimidine compound and its application

The invention relates to a new N- phenyl-2-aminopyrimidine compound and a medicine composition containing the compound; the N- phenyl-2-aminopyrimidine compound is applied to treat related disease or symptoms of epidermal growth factor receptor (EGFR), such as treat or improve abnormal cell proliferative disease like cancer.

N-Heterocyclic carbenes derived from imidazo-[1,5-a]pyridines related to natural products: synthesis, structure and potential biological activity of some corresponding gold(I) and silver(I) complexes

A series of Au(I) complexes (12, 13, 14, 15, 16) and Ag(I) complexes (17, 18, 19, 20) derived from imidazo[1,5-a]pyridin-3-ylidenes were synthesized from AuCl(SMe2) or by reacting silver(I) acetate with 2,5-dimethylimidazo[1,5-a]pyridin-2-ium iodide or imidazo[1,5-a]pyridin-2-ium salts, and were characterized using NMR spectroscopy, mass spectrometry and elemental analyses. In addition, the Au(I) complex 13 and the Ag(I) complex 19 were characterized using single-crystal X-ray diffraction. Using paclitaxel as a standard, all Au(I) and Ag(I) N-heterocyclic carbene complexes were evaluated for their in vitro anti-tumour activity against 12 cell lines using a monolayer cell survival and proliferation assay. The highest anticancer activity was found for complexes 15, 13 and 14 with mean IC50 values of 10.09, 10.42 and 12.28?μM, respectively. Copyright

Substituted imidazo[1,5-A]pyridines

Disclosed are e.g. novel 5-(carboxyalkyl)imidazo[1,5-a]pyridines, their derivatives and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombo

A DIRECT METHOD FOR THE SUBSTITUTION OF IMIDAZOPYRIDINES AT POSITION 5

3-Ethylthioimidazopyridine lithiates at carbon 5.Quenching of the anion with an electrophile followed by desulphurisation gives 5-substituted imidazopyridines.