5-Methylimidazo[1,5-a]pyridine

Base Information

• Chemical Name: 5-Methylimidazo[1,5-a]pyridine
• CAS No.: 6558-64-1
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80480644
• Nikkaji Number: J2.164.600H
• Wikidata: Q82315585
• Mol file: 6558-64-1.mol

Synonyms:5-methylimidazo[1,5-a]pyridine;6558-64-1;5-Methyl-imidazo[1,5-a]pyridine;SCHEMBL9123926;DTXSID80480644;AMTVPXODMPYFPU-UHFFFAOYSA-N;MFCD09953156;AKOS006310684;SB38148;AS-30842;5-Methyl-imidazo[1 pound not5-a]pyridine;CS-0341947;FT-0704398

Chemical Property of 5-Methylimidazo[1,5-a]pyridine

Chemical Property:

• Refractive Index: 1.609
• Boiling Point: 95-98 °C(Press: 0.1 Torr)
• PKA: 7.81±0.30(Predicted)
• PSA: 17.30000
• Density: 1.113 g/cm³
• LogP: 1.64270
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 132.068748264
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-imidazo[1,5-A]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC2=CN=CN12

Technology Process of 5-Methylimidazo[1,5-a]pyridine

There total 8 articles about 5-Methylimidazo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.8%

N-((6-methylpyridin-2-yl)methyl)formamide (54384-88-2) → 5-methylimidazo<1,5-a>pyridine (6558-64-1)

Guidance literature:

In trichlorophosphate; at 20 - 100 ℃; Inert atmosphere;

Reference yield:

3-ethylthio-5-methylimidazo<1,5-a>pyridine (76266-05-2) → 5-methylimidazo<1,5-a>pyridine (6558-64-1)

Guidance literature:

With nickel; In ethanol; Heating;

DOI:10.1016/S0040-4039(00)78996-9

Reference yield:

imidazo[1,5-a]pyridine-3-thiol (76259-00-2) → 5-methylimidazo<1,5-a>pyridine (6558-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / acetone / 45 °C

2: 1.) n-butyl lithium / 1.) THF, -78 deg C; 2.) from -78 deg C to room temperature

3: Raney nickel / ethanol / Heating

With n-butyllithium; nickel; potassium carbonate; In ethanol; acetone;

DOI:10.1016/S0040-4039(00)78996-9

upstream raw materials:

3-ethylthio-5-methylimidazo<1,5-a>pyridine

imidazo[1,5-a]pyridine-3-thiol

3-ethylsulfanyl-imidazo[1,5-a]pyridine

2-(Aminomethyl)pyridine

Downstream raw materials:

2-benzyl-5-methylimidazo[1,5-a]pyridine-3-ylidene

pirmagrel