65581-29-5

Upstream product

• 2389-45-9 Boc-Lys(Z)-OH 
• 67-56-1 methanol 
• 189188-67-8 ((S)-4-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexyl)-carbamic acid benzyl ester 
• 172833-14-6 ((S)-5-tert-Butoxycarbonylamino-7-diazo-6-oxo-heptyl)-carbamic acid benzyl ester 

Downstream Products

• 153074-94-3 (S)-7-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-heptanoic acid methyl ester 
• 153074-75-0 (S)-3-(3-Adamantan-1-yl-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester 
• 153074-87-4 (S)-7-Benzyloxycarbonylamino-3-[3-(4-methoxy-phenyl)-propionylamino]-heptanoic acid methyl ester 
• 153074-73-8 (S)-3-(2-Adamantan-1-yl-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester 
• 153074-72-7 (S)-6-Benzyloxycarbonylamino-3-[3-(4-methoxy-phenyl)-propionylamino]-hexanoic acid methyl ester 
• 153074-69-2 (S)-6-Benzyloxycarbonylamino-3-(toluene-4-sulfonylamino)-hexanoic acid methyl ester 

Relevant academic research and scientific papers

Peptidyl β-homo-aspartals: Specific inhibitors of interleukin-1β converting enzyme and its homologues (caspases)

Inhibition of interleukin-1β convening enzyme (ICE), apopain, papain, thrombin and trypsin with substrate like peptidyl L- and D-α-aldehydes and their L-β-homo-aldehyde analogues was investigated. The L-β-homo-aspartals appear to be specific inhibitors fo

Beta-amino acid derivatives as orally active non-peptide fibrinogen receptor antagonists

The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of the platelet fibrinogen receptor GPIIb/IIIa.