656-49-5

Basic information

• Product Name: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE
• Synonyms: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE;5-chloro-2-(trifluoromethyl)-benzimidazol;2-(Trifluoromethyl)-5-chloro-1H-benzimidazole;5-Chloro-2-trifluoromethyl-1H-benzimidazole;5-Chloro-2-(trifluoromethyl)-1H-benzo[d]imidazole
• CAS NO: 656-49-5
• Molecular Formula: C8H4ClF3N2
• Molecular Weight: 220.58
• Product Categories: Imidazol&Benzimidazole
• Mol File: 656-49-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 203 °C
• Boiling Point: 301 °C at 760 mmHg
• Flash Point: 135.9 °C
• Appearance: /
• Density: 1.569 g/cm³
• Vapor Pressure: 0.00193mmHg at 25°C
• Refractive Index: 1.575
• PKA: 8.49±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE(656-49-5)
• EPA Substance Registry System: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE(656-49-5)

Safety Data

• Hazardous Substances Data: 656-49-5(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE is a chemical compound that contains a benzimidazole ring with a chlorine substituent at the 5th position and a trifluoromethyl group at the 2nd position. It is categorized as a benzimidazole derivative and is commonly used in pharmaceutical research and drug development. 5-CHLORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE has potential medicinal properties and is being investigated for its various biological activities, including anticancer, anti-inflammatory, and antimicrobial effects. Its unique structure and chemical properties make it a promising candidate for the development of new therapeutics for a wide range of medical conditions.

InChI:InChI=1/C8H4ClF3N2/c9-4-1-2-5-6(3-4)14-7(13-5)8(10,11)12/h1-3H,(H,13,14)

Upstream product

• 89-63-4 4-Chloro-2-nitroaniline 
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• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 76-05-1 trifluoroacetic acid 
• 1522-22-1 1,1,1,5,5,5-hexafluoroacetylacetone 

Downstream Products

• 14689-60-2 4,6,7-Tribromo-5-chloro-2-trifluoromethylbenzimidazole0 

Relevant articles and documents

Fe(OTf)3-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles from o-arylenediamines and hexafluoroacetylacetone

An iron-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles through condensation of o-arylenediamines and hexafluoroacetylacetone followed by intramolecular addition and C–C bond cleavage in one-pot has been developed. A series of title compounds were obtained with up to 99% yield. This method is quite practical and suitable for scalable preparation due to simple experimental procedure and readily available reagents.

Synthesis and antiparasitic activity of 2-(Trifluoromethyl)benzimidazole derivatives

2-(Trifluoromethyl)benzimidazole derivatives substituted at the 1-, 5-, and 6-positions have been synthesized and in vitro tested against the protozoa Giardia lamblia, Entamoeba histolytica, and the helminth Trichinella spiralis. Results indicate that all the compounds tested are more active as antiprotozoal agents than Albendazole and Metronidazole. One compound (20) was as active as Albendazole against T. spiralis. These compounds were also tested for their effect on tubulin polymerization and none inhibited tubulin polymerization.