6560-83-4

Basic information

• Product Name: 2-IODOQUINOLINE
• Synonyms: 2-IODOQUINOLINE;2-iodo-quinolin;Nsc 56811;Quinoline, 2-iodo-
• CAS NO: 6560-83-4
• Molecular Formula: C₉H₆IN
• Molecular Weight: 255.06
• Mol File: 6560-83-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 320.7 °C at 760 mmHg
• Flash Point: 147.8 °C
• Appearance: /
• Density: 1.837 g/cm³
• Vapor Pressure: 0.000585mmHg at 25°C
• Refractive Index: 1.724
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.67±0.40(Predicted)
• CAS DataBase Reference: 2-IODOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODOQUINOLINE(6560-83-4)
• EPA Substance Registry System: 2-IODOQUINOLINE(6560-83-4)

Safety Data

• Hazardous Substances Data: 6560-83-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6757, 1990 DOI: 10.1016/S0040-4039(00)97163-6Chemical and Pharmaceutical Bulletin, 30, p. 1731, 1982 DOI: 10.1248/cpb.30.1731

InChI:InChI=1/C9H6IN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H

Upstream product

• 612-62-4 2-Chloroquinoline 
• 91-22-5 quinoline 
• 109586-44-9 trifluoromethanesulfonic acid quinolin-2-yl ester 
• 79476-04-3 (2-quinolyl)trimethylstannane 
• 10034-85-2 hydrogen iodide 
• 59-31-4 2-hydroxyquinoline 

Downstream Products

• 91-22-5 quinoline 
• 34243-33-9 2-thiophen-2-yl-quinoline 
• 83036-89-9 2-(1H-pyrrol-2-yl)quinoline 
• 129887-31-6 2-(1H-pyrrol-3-yl)quinoline 
• 1006889-89-9 7-methoxy-4-(3-phenylpiperidin-1-yl)-6-[(3-quinolin-2-ylprop-2-yn-1-yl)oxy]quinazoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 1203646-06-3 2-quinolinyltriphenylphosphonium iodide 
• 62141-43-9 2-(4-methylbenzenesulfonyl)quinoline 
• 40279-26-3 2-(methylthio)quinoline 
• 17075-19-3 2-(methylsulfonyl)quinoline 
• 16576-25-3 2-benzoylquinoline 
• 64495-58-5 2-benzenesulfonyl-quinoline 

Relevant articles and documents

Iodopyridines from bromo- and chloropyridines

Bromo- and chloropyridines may be converted to the corresponding iodopyridines by treatment with sodium iodide and acetyl chloride in acetonitrile.

Probing the catalytic promiscuity of a regio- and stereospecific C-glycosyltransferase from Mangifera indica

The catalytic promiscuity of the novel benzophenone C-glycosyltransferase, MiCGT, which is involved in the biosynthesis of mangiferin from Mangifera indica, was explored. MiCGT exhibited a robust capability to regio- and stereospecific C-glycosylation of 35 structurally diverse druglike scaffolds and simple phenolics with UDP-glucose, and also formed O- and N-glycosides. Moreover, MiCGT was able to generate C-xylosides with UDP-xylose. The OGT-reversibility of MiCGT was also exploited to generate C-glucosides with simple sugar donor. Three aryl-C-glycosides exhibited potent SGLT2 inhibitory activities with IC50 values of 2.6×, 7.6×, and 7.6×10-7-M, respectively. These findings demonstrate for the first time the significant potential of an enzymatic approach to diversification through C-glycosidation of bioactive natural and unnatural products in drug discovery. C-glycodiversification: MiCGT, as the first benzophenone C-glycosyltransferase (CGT) from Mangifera indica, showed robust regio- and stereospecific C-glycosylation activity for 35 structurally diverse acceptors with UDP-glucose or xylose. The aryl-C-glycoside 1 exhibited potent antidiabetic activity toward SGLT2.

AMINO-HETEROCYCLIC COMPOUNDS

The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, A, and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.