65608-73-3Relevant articles and documents
Palladium-Catalyzed Synthesis of Allylic Ureas via an Isocyanate Intermediate
Jay, Lucien P.,Barker, Timothy J.
, p. 1829 - 1831 (2016/05/09)
A palladium-catalyzed coupling of allylic carbonates with trimethylsilylisocyanate to provide allylic isocyanates is reported. Amines are added in a second step to yield allylic ureas in this one-pot procedure. Use of a bidentate phosphine ligand with a large bite angle was found to be important in this transformation. The scope of allylic carbonates has been examined, as well as amines compatible with these reaction conditions.
Kinetics and mechanism of the aminolysis of aryl n-allyl thiocarbamates in acetonitrile
Lee, Hanna,Oh, Hyuck Keun
experimental part, p. 475 - 478 (2010/07/15)
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A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists
Guo, Zhiqiang,Wu, Dongpei,Zhu, Yun-Fei,Tucci, Fabio C.,Pontillo, Joseph,Saunders, John,Xie, Qiu,Struthers, R. Scott,Chen, Chen
, p. 693 - 698 (2007/10/03)
A convenient one-pot synthetic route was developed for the preparation of asymmetric 1,3-dialkyl-1,3,5-triazine-2,4,6-triones from readily available alkyl- or aryl-isocyanates, primary amines and N-chlorocarbonyl isocyanate in excellent yields. Subsequent alkylation with N-protected amino alcohols afforded the desired 1,3,5-triazine-2,4,6-triones in good yields. This methodology was applied to the synthesis of a chemical library acting as antagonists of the hGnRH receptor.
