65608-73-3

Upstream product

• 1476-23-9 allylisocyanate 
• 100-46-9 benzylamine 
• 107-11-9 1-amino-2-propene 
• 3173-56-6 benzyl isothiocyanate 
• 1262963-23-4 CH₂CHCH₂-NHC(CO)SC₆H₄-p-Br 
• 14467-73-3 phenyl N-allylthiocarbamate 
• 72024-43-2 CH₂CHCH₂-NHC(CO)SC₆H₄-p-CH₃ 
• 14467-77-7 CH₂CHCH₂-NHC(CO)SC₆H₄-p-Cl 
• 16250-37-6 N-allylformamide 

Downstream Products

• 1131457-31-2 1,5-dibenzylimidazolidin-2-one 
• 91180-75-5 benzyl-(5-methyl-4,5-dihydro-oxazol-2-yl)-amine 

Relevant academic research and scientific papers

Palladium-Catalyzed Synthesis of Allylic Ureas via an Isocyanate Intermediate

A palladium-catalyzed coupling of allylic carbonates with trimethylsilylisocyanate to provide allylic isocyanates is reported. Amines are added in a second step to yield allylic ureas in this one-pot procedure. Use of a bidentate phosphine ligand with a large bite angle was found to be important in this transformation. The scope of allylic carbonates has been examined, as well as amines compatible with these reaction conditions.

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines

The efficient removal of primary and secondary amines from organic solutions using a macroporous polymer-supported anhydride is described. The sequestering of primary amines by the anhydride via polymer-bound amide formation is completed within 2-4 h at r

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists

A convenient one-pot synthetic route was developed for the preparation of asymmetric 1,3-dialkyl-1,3,5-triazine-2,4,6-triones from readily available alkyl- or aryl-isocyanates, primary amines and N-chlorocarbonyl isocyanate in excellent yields. Subsequent alkylation with N-protected amino alcohols afforded the desired 1,3,5-triazine-2,4,6-triones in good yields. This methodology was applied to the synthesis of a chemical library acting as antagonists of the hGnRH receptor.