65608-82-4

Upstream product

• 873-76-7 para-Chlorobenzyl alcohol 
• 107-12-0 propiononitrile 
• 18245-72-2 S-phenylthiopropionate 
• 104-86-9 4-chlorobenzylamine 
• 18241-63-9 p-methylphenyl thiolmethylacetate 
• 76542-10-4 S-(4-chlorophenyl) propanethioate 
• 287471-39-0 m-chlorophenyl thiolmethylacetate 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 79-05-0 Propionamid 

Downstream Products

• 103275-32-7 (4-chloro-benzyl)-propyl-amine; hydrochloride 

Relevant academic research and scientific papers

Selective catalytic sp3 C-O bond cleavage with C-N bond formation in 3-alkoxy-1-propanols

The ruthenium catalyzed selective sp3 C-O cleavage with amide formation was reported in reactions of 3-alkoxy-1-propanol derivatives and amines. The cleavage only occurs at the C3-O position even with 3-benzyloxy-1-propanol. Based on the experimental results, O-bound and C-bound Ru enolate complexes were proposed as key intermediates for the unique selective sp3 C-O bond cleavage in 3-alkoxy-1-propanols.

Transamidation catalyzed by a recoverable and reusable polyDMAP-based hafnium chloride and montmorillonite KSF

In this article, we described the use of an easily available polymer-based hafnium chloride and montmorillonite KSF catalyst (HfCl4/KSF- polyDMAP) in transamidation under relatively mild conditions. This metal catalyst can be easily recovered and reused in this reaction to give the corresponding amides in good yields. Copyright Taylor & Francis, Inc.

METHOD OF PROCESSING OF HYDROGEN FOR REDUCTIVE ACYLATION OF NITRO, AZIDO AND CYANO ARENES

The present invention relates to a method for processing of hydrogen for the reductive acylation of nitro, azido and cyano arenes. More particularly, this invention relates to an improved process for the preparation of amides and anilides using C3-C7 carboxylic acids as proton source/acylating agents employing Fe3+-montmorillonite as a catalyst.

Method of processing of hydrogen for reductive acylation of nitro, azido and cyano arenes

A method for processing of hydrogen for the reductive acylation of nitro, azido and cyano arenes is disclosed. More particularly, improved process for the preparation of amides and anilides using C3-C7carboxylic acids as proton source/acylating agents employing Fe3+-montmorillonite as a catalyst is disclosed.

Kinetics and mechanism of the aminolysis of thiophenyl methylacetates in acetonitrile

The aminolysis of Z-thiophenyl methylacetates (C2H5C(double bond O)SC6H4Z) with X-benzylamines in acetonitrile has been investigated at 45 °C. The reaction is found to proceed by a stepwise mechanism in which the rate-determining step is the breakdown of the zwitterionic tetrahedral intermediate, T±, with possibly a hydrogen-bonded four-center-type transition state. These mechanistic conclusions are drawn based on (i) the large magnitude of βX (= 1.2 to approximately 2.5) and βz (= -0.9 to approximately -1.5), (ii) the normal kinetic isotope effects (kH/kD?1.2) involving deuterated benzylamines (XC6H4CH2ND2), (iii) a large positive ρxz (= 2.4) and (iv) adherence to the reactivity-selectivity principle in all cases. The extremely large βX (βnuc) values can be accounted for by the loss of a strong localized cationic charge on the N atom of benzylamines in the expulsion from the T±. The pKa° (≥10.0) is high due to a large ratio of the expulsion rates of the amine (k-a) to thiophenolate (kb) (k-a/kb) from the T±.

Highly selective amidation of benzylic alcohols with nitriles. A modified ritter reaction

Benzyl alcohols react selectively with different nitriles in the presence of a catalytic amount of boron trifluoride and produce amides in high yields. Deactivated p-nitrobenzyl, allylic, primary, secondary, and tertiary saturated alcohols do not react.