65608-82-4

Basic information

• Product Name: PropanaMide, N-[(4-chlorophenyl)Methyl]-
• Synonyms: PropanaMide, N-[(4-chlorophenyl)Methyl]-;N-(4-chlorobenzyl)propanamide
• CAS NO: 65608-82-4
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66138
• Mol File: 65608-82-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PropanaMide, N-[(4-chlorophenyl)Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: PropanaMide, N-[(4-chlorophenyl)Methyl]-(65608-82-4)
• EPA Substance Registry System: PropanaMide, N-[(4-chlorophenyl)Methyl]-(65608-82-4)

Safety Data

• Hazardous Substances Data: 65608-82-4(Hazardous Substances Data)

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 79-05-0 Propionamid 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 287471-39-0 m-chlorophenyl thiolmethylacetate 
• 76542-10-4 S-(4-chlorophenyl) propanethioate 
• 18241-63-9 p-methylphenyl thiolmethylacetate 
• 18245-72-2 S-phenylthiopropionate 
• 873-76-7 para-Chlorobenzyl alcohol 
• 107-12-0 propiononitrile 

Downstream Products

• 103275-32-7 (4-chloro-benzyl)-propyl-amine; hydrochloride 

Relevant articles and documents

Selective catalytic sp3 C-O bond cleavage with C-N bond formation in 3-alkoxy-1-propanols

The ruthenium catalyzed selective sp3 C-O cleavage with amide formation was reported in reactions of 3-alkoxy-1-propanol derivatives and amines. The cleavage only occurs at the C3-O position even with 3-benzyloxy-1-propanol. Based on the experimental results, O-bound and C-bound Ru enolate complexes were proposed as key intermediates for the unique selective sp3 C-O bond cleavage in 3-alkoxy-1-propanols.

METHOD OF PROCESSING OF HYDROGEN FOR REDUCTIVE ACYLATION OF NITRO, AZIDO AND CYANO ARENES

The present invention relates to a method for processing of hydrogen for the reductive acylation of nitro, azido and cyano arenes. More particularly, this invention relates to an improved process for the preparation of amides and anilides using C3-C7 carboxylic acids as proton source/acylating agents employing Fe3+-montmorillonite as a catalyst.

Kinetics and mechanism of the aminolysis of thiophenyl methylacetates in acetonitrile

The aminolysis of Z-thiophenyl methylacetates (C2H5C(double bond O)SC6H4Z) with X-benzylamines in acetonitrile has been investigated at 45 °C. The reaction is found to proceed by a stepwise mechanism in which the rate-determining step is the breakdown of the zwitterionic tetrahedral intermediate, T±, with possibly a hydrogen-bonded four-center-type transition state. These mechanistic conclusions are drawn based on (i) the large magnitude of βX (= 1.2 to approximately 2.5) and βz (= -0.9 to approximately -1.5), (ii) the normal kinetic isotope effects (kH/kD?1.2) involving deuterated benzylamines (XC6H4CH2ND2), (iii) a large positive ρxz (= 2.4) and (iv) adherence to the reactivity-selectivity principle in all cases. The extremely large βX (βnuc) values can be accounted for by the loss of a strong localized cationic charge on the N atom of benzylamines in the expulsion from the T±. The pKa° (≥10.0) is high due to a large ratio of the expulsion rates of the amine (k-a) to thiophenolate (kb) (k-a/kb) from the T±.