65615-89-6

Basic information

• Product Name: N-Boc-4-nitro-L-phenylalanine Methyl Ester
• Synonyms: Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-nitrophenyl)propanoate;N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine Methyl Ester;N-[(1,1-Dimethylethoxy)carbonyl]-4-nitro-L-phenylalanine Methyl Ester;N-Boc-4-nitro-L-phenylalanine Methyl Ester;methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoate;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, methyl ester
• CAS NO: 65615-89-6
• Molecular Formula: C₁₅H₂₀N₂O₆
• Molecular Weight: 324.33
• Product Categories: Chemical Amines;Amines;Aromatics;Chiral Reagents
• Mol File: 65615-89-6.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 471.136°C at 760 mmHg
• Flash Point: 238.735°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: N-Boc-4-nitro-L-phenylalanine Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-4-nitro-L-phenylalanine Methyl Ester(65615-89-6)
• EPA Substance Registry System: N-Boc-4-nitro-L-phenylalanine Methyl Ester(65615-89-6)

Safety Data

• Hazardous Substances Data: 65615-89-6(Hazardous Substances Data)

Usage

Description

N-Boc-4-nitro-L-phenylalanine Methyl Ester, with the CAS number 65615-89-6, is a white solid compound that plays a significant role in organic synthesis. It is a derivative of L-phenylalanine, an essential amino acid, with a nitro group at the 4-position and a Boc-protecting group and a methyl ester functional group attached to it.

Uses

Used in Organic Synthesis:
N-Boc-4-nitro-L-phenylalanine Methyl Ester is used as a synthetic intermediate for the preparation of various pharmaceutical compounds and bioactive molecules. Its unique structure allows for the creation of complex organic molecules with potential applications in the pharmaceutical and chemical industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Boc-4-nitro-L-phenylalanine Methyl Ester is used as a building block for the development of new drugs. Its versatile structure enables the synthesis of a wide range of therapeutic agents, including those targeting specific diseases or conditions.
Used in Chemical Research:
N-Boc-4-nitro-L-phenylalanine Methyl Ester is also utilized in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic routes. Its reactivity and functional groups make it an ideal candidate for investigating novel chemical transformations and understanding the underlying principles of organic chemistry.

InChI:InChI=1/C15H20N2O6/c1-15(2,3)23-14(19)16-12(13(18)22-4)9-10-5-7-11(8-6-10)17(20)21/h5-8,12H,9H2,1-4H3,(H,16,19)/t12-/m0/s1

Upstream product

• 33305-77-0 Boc-Phe(p-NO₂)-OH 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 77-78-1 dimethyl sulfate 
• 17193-40-7 (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride 
• 682774-41-0 [1-(S)-2-phenyl-1-(2-trimethylsilanylethoxymethoxymethyl)ethyl]carbamic acid tert-butyl ester 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 186581-53-3 diazomethane 
• 17763-80-3 para-nitrophenyl triflate 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 114346-29-1 tert-butyl N-[(2S)-1-hydroxy-3-(4-nitrophenyl)propan-2-yl]carbamate 

Relevant articles and documents

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An Optically Active Polymer for Broad-Spectrum Enantiomeric Recognition of Chiral Acids

Recognition of enantiomers of chiral acids by anion–π or lone pair–π interactions has not yet been investigated but is a significant and attractive challenge. This study reports an optically active polymer-based supramolecular system with capabilities of discriminating enantiomers of various chiral acids. The polymer featuring alternate π-acidic naphthalenediimides (NDIs) and methyl l-phenylalaninates in the backbone exhibits an unprecedented slow self-assembly process that is susceptible to perturbation by various chiral acids. Thus, the combination of anion–π or lone pair–π interactions and sensitivity of the polymeric self-assembly process to external chiral species endows the system with recognition capabilities. This is the first time that anion–π or lone pair–π interactions have been applied in the recognition of enantiomers of various chiral acids with a single system. The results shed light on new strategies for material design by integrating π-acidic aromatic systems and chiral building blocks to afford relevant advanced functions.