65619-28-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Cyano-4-(4-bromophenyl)cyclohexanone is used as a starting material for the synthesis of various pharmaceutical products. Its chemical structure allows for the introduction of a diverse range of substituents, enabling the development of compounds with a wide variety of properties and applications in the pharmaceutical field.
Used in Agrochemical Industry:
4-Cyano-4-(4-bromophenyl)cyclohexanone is also used as a starting material for the synthesis of various agrochemical products. Its unique chemical structure contributes to the development of compounds with specific properties and applications in agriculture, such as pesticides and herbicides.
Used in Organic Synthesis:
4-Cyano-4-(4-bromophenyl)cyclohexanone serves as a valuable building block in organic synthesis. Its cyano and bromophenyl groups make it a versatile compound for the creation of related compounds with different properties and uses, further expanding its applications in various industries.

Upstream product

• 626603-27-8 1-(4-bromophenyl)cyclohexane-1-carbonitrile 
• 65620-26-0 4-(p-Bromphenyl)-4-cyanopimelinsaeuredimethylester 
• 16532-79-9 4-Bromophenylacetonitrile 
• 140-88-5 ethyl acrylate 
• 65619-24-1 4-(p-Bromphenyl)-2-carbomethoxy-4-cyano-cyclohexanon 

Downstream Products

• 65619-32-1 8-(4-Bromo-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 79741-34-7 [8-(4-Bromo-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-methyl-amine 
• 65619-40-1 8-(4-Bromo-phenyl)-8-isocyanato-1,4-dioxa-spiro[4.5]decane 
• 65619-36-5 8-(4-Bromo-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid 
• 71368-46-2 4-(p-bromophenyl)-4-dimethylaminocyclohexan-1-one. ethylene ketal 

Relevant academic research and scientific papers

CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES

A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

Chemoselective methylene oxidation in aromatic molecules

Despite significant progress in the development of site-selective aliphatic C–H oxidations over the past decade, the ability to oxidize strong methylene C–H bonds in the presence of more oxidatively labile aromatic functionalities remains a major unsolved

Fluorinated oxabicycl oxononanoic structure and its liquid crystal composition having compd.

PROBLEM TO BE SOLVED: To provide a liquid crystal composition and a display element having negative dielectric anisotropy (Δε) of a large absolute value and being excellent in chemical stability, and to provide a compound having negative Δε of a large

Fluorinated oxabicycl oxononanoic structure and its liquid crystal composition having compd.

PROBLEM TO BE SOLVED: To provide a liquid crystal composition and a display element having negative dielectric anisotropy (Δε) of a large absolute value and being excellent in chemical stability, and a compound having negative dielectric anisotropy (Δε

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.