65625-13-0Relevant academic research and scientific papers
Synthesis of some novel 3,4,5-trisubstituted triazole derivatives bearing quinoline ring and evaluation of their antimicrobial activity
Yurtta?, Leyla,Kubilay, Asl?han,Evren, Asaf Evrim,K?sac?k, ?pek,Karaca Gen?er, Hülya
, p. 767 - 773 (2020/05/25)
Some new 3,4,5-trisubstituted 1,2,4-triazole derivatives were synthesized and studied for their antimicrobial activity. The lead compounds were obtained starting from 8-hydroxyquinoline and ethyl 2-chloroacetate. The obtained ester compound (1) first reac
Regioselective synthesis, antitumor and antioxidant activities of some 1,2,4-triazole derivatives based on 4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol
Behalo,Amine,Fouda
, p. 410 - 417 (2017/04/03)
Regioselective synthesis of some triazole derivatives 4–18 was achieved from the versatile, readily accessible 4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol/thione 3. The structures of the newly synthesized products were confirmed and characterized by IR, 1H NMR, 13C NMR, and mass spectral studies. Most of the synthesized compounds were evaluated for their antitumor and antioxidant activities and demonstrated potent to weak activities.
Synthesis of new 8-(5-substituted amino-1,3,4-oxadiazol-2-yl) and 8-(5-substitued amino-1,3,4-thiadiazol-2-yl) methoxyquinolines with antibilharzial activity
Soliman,Mokhtar,El Sadany
, p. 403 - 405 (2007/10/02)
Several 5-substituted amino-1,3,4-oxadiazol-2-yl and 5-substituted amino-1,3,4-thiadiazol-2-yl derivatives with different 8-hydroxyquinoline moieties in the 2-position were prepared and tested for their antiparasitic activity. Preliminary biological tests on mice experimentally infested with Schistosoma mansoni revealed that the new compounds show moderate schistosomicidal activity.
