656257-05-5

Basic information

• Product Name: TERT-BUTYL 2-(METHOXYMETHYL)INDOLINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 2-(METHOXYMETHYL)INDOLINE-1-CARBOXYLATE
• CAS NO: 656257-05-5
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.33
• Mol File: 656257-05-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL 2-(METHOXYMETHYL)INDOLINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-(METHOXYMETHYL)INDOLINE-1-CARBOXYLATE(656257-05-5)
• EPA Substance Registry System: TERT-BUTYL 2-(METHOXYMETHYL)INDOLINE-1-CARBOXYLATE(656257-05-5)

Safety Data

• Hazardous Substances Data: 656257-05-5(Hazardous Substances Data)

Upstream product

• 172647-87-9 tert-butyl 2-(hydroxymethyl)indoline-1-carboxylate 
• 74-88-4 methyl iodide 
• 137088-51-8 1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid 
• 16851-56-2 indolin-2-yl carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 365250-59-5 2-(methoxymethyl)indoline 

Relevant articles and documents

Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: Benzopyranyl indoline and indole analogues

This paper describes the design, syntheses, and biological evaluations of novel ATP-sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives. Among those, two enantiomers of indoline-2-carboxylic ethyl esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation >30 μM). The cardioprotective effect of 14 was completely reversed by 5-hydroxydecanoate, a selective mitochondrial KATP blocker, indicating its provable protective mechanism through the mitochondrial KATP opening. In addition, we performed conformational analyses using 2D-NMR, X-ray crystallography and molecular modeling to study the structure-activity relationships in this series of compounds.