656257-45-3

Usage

Uses

1-Ethyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine

InChI:InChI=1/C18H31BN2O3/c1-6-20-11-13-21(14-12-20)16-9-7-15(8-10-16)19(23)24-18(4,5)17(2,3)22/h7-10,22-23H,6,11-14H2,1-5H3

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 5308-25-8 4-ethylpiperazine 
• 73183-34-3 bis(pinacol)diborane 
• 656257-43-1 1-(4-bromophenyl)-4-ethylpiperazine 
• 66698-28-0 1-(4-bromophenyl)piperazine 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 1247003-79-7 (1R,2S)-2-(3-(4-(4-ethylpiperazin-1-yl)phenyl)-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one 

Relevant academic research and scientific papers

CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS

The invention provides a series of chlorobenzene substituted azaaryl compounds having activity in inhibiting cancer cell growth and low toxicity to normal cells. Particularly, the compounds of the invention have stronger inhibition effect on bladder cance

Imidazothiazolone deriv.

PROBLEM TO BE SOLVED: To provide a compound having excellent Pim kinase inhibitory action and useful as anticancer agent, and a medicament comprising the compound.SOLUTION: This invention relates to a thiazolone derivative compound represented by the following compound, and a medicament comprising the compound.

2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS

This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.