656257-75-9

Upstream product

• 656239-37-1 4-(4,4,5,5-tetramethyl-[1,2,3]-dioxaborolan-2-yl)-N-(tetrahydropyran-4-yl)-benzamide 
• 656257-70-4 1-[2-bromo-pyridin-4-yl]-2-[6-methyl-pyridin-2-yl]-ethanone 

Downstream Products

• 657399-17-2 3-[2-(4-((tetrahvdropyran-4-yl)aminocarbonyl)phenyl)pyridin-4-yl]-4-(6-methylpyridin-2-yl)-1H-pyrazole 
• 657399-17-2 3-[2-(4-((tetrahydropyran-4-yl)aminocarbonyl)phenyl)pyridin-4-yl]-4-[6-methylpyridin-2-yl]-1H-pyrazole 

Relevant academic research and scientific papers

PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR

The invention relates to novel pyrazole derivatives of formula (I), which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS

This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.