65642-03-7Relevant academic research and scientific papers
Preparation of N-Arylquinazolinium Salts via a Cascade Approach
Ramanathan, Mani,Wan, Jing,Liu, Shiuh-Tzung
, p. 7459 - 7467 (2019)
An easy manipulation method for the preparation of N-arylquinazolinium salts is described from readily available aryldiazonium salts, nitriles, and 2-aminoarylketones in a one-pot operation. This method relies on the in situ generation of the N-arylnitrilium intermediate from the reaction of aryldiazonium salt with nitrile, which undergoes amination/cascade cyclization/aromatization, leading to N-arylquinazolinium salts in excellent yields. Nucleophilic addition of alkoxide to these N-arylquinazolinium salts provides functionalized dihydro-N-arylquinazoline.
