6566-42-3Relevant academic research and scientific papers
Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance
Wang, Yinhu,Mowla, Rumana,Guo, Liwei,Ogunniyi, Abiodun D.,Rahman, Taufiq,De Barros Lopes, Miguel A.,Ma, Shutao,Venter, Henrietta
supporting information, p. 733 - 739 (2017/02/10)
Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these pumps important drug targets. We have synthesised a novel series of compounds based on a 2-naphthamide pharmacore aimed at inhibiting the efflux pumps from Gram-negativ
Disubstituted bicyclic derivative and application thereof as efflux pump inhibitor to anti-microbial
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Paragraph 0100; 0101; 0102, (2017/04/28)
The invention discloses a disubstituted bicyclic derivative and application thereof as an efflux pump inhibitor to anti-microbial. It is proved by experiments that the disubstituted bicyclic derivative has a good inhibition function on multidrug-resistant bacteria carrying an AcrB efflux pump and can effectively recover or enhance antibacterial efficiency of existing antibiotics. The chemical structural formula of the disubstituted bicyclic derivative is as shown in a formula (I) (the formula can be seen in specification), and R1, R2, X, Y, Z and W are as defined in the specification.
