1573-91-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Naphthalenecarboxylic acid, 4-hydroxy-, is used as a building block in the synthesis of various pharmaceuticals due to its unique chemical structure. Its presence in the molecular framework allows for the development of new drugs with potential therapeutic benefits.
Used in Enzyme Inhibition:
2-Naphthalenecarboxylic acid, 4-hydroxyserves as an inhibitor of certain enzymes, making it a valuable tool in the study and regulation of enzymatic processes. By targeting specific enzymes, 2-naphthoic acid, 4-hydroxy-, can help modulate biological pathways and potentially treat diseases associated with enzyme dysregulation.
Used in Organic Synthesis as a Precursor:
2-Naphthalenecarboxylic acid, 4-hydroxy-, is utilized as a precursor in the synthesis of other organic compounds. Its versatile chemical properties enable the creation of a wide range of molecules with various applications in different industries.
Used in Research and Development of New Drugs and Materials:
The unique chemical properties of 2-naphthoic acid, 4-hydroxy-, make it a valuable asset in the research and development of new drugs and materials. Its potential applications in biological and pharmaceutical fields contribute to the advancement of medical and chemical sciences.

InChI:InChI=1/C11H8O3/c12-10-6-8(11(13)14)5-7-3-1-2-4-9(7)10/h1-6,12H,(H,13,14)

Upstream product

• 6566-40-1 4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 91135-42-1 4-amino-[2]naphthonitrile 
• 5773-98-8 4-Amino-[2]naphthoesaeure 
• 91-66-7 N,N-diethylaniline 
• 93-09-4 naphthalene-2-carboxylate 
• 5653-88-3 trans-phenylitaconic acid 
• 5653-88-3 2-benzylidenesuccinic acid 
• 68376-15-8 diethyl 1-hydroxy-2,3-naphthalene dicarboxylate 
• 33295-46-4 ethyl 4-acetoxynaphthalene-2-carboxylate 

Downstream Products

• 123239-64-5 4-methoxynaphthalene-2-carbaldehyde 
• 33295-47-5 methyl 4-methoxynaphthalene-2-carboxylate 
• 34205-71-5 methyl 4-hydroxy-2-naphthalenecarboxylate 
• 5773-93-3 4-methoxy-2-naphthoic acid 
• 6566-42-3 4-acetoxy-2-naphthoic acid 
• 91307-39-0 ethyl 1,2,3,4-tetrahydro-4-hydroxy-2-naphthoate 

Relevant academic research and scientific papers

Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance

Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these pumps important drug targets. We have synthesised a novel series of compounds based on a 2-naphthamide pharmacore aimed at inhibiting the efflux pumps from Gram-negativ

Disubstituted bicyclic derivative and application thereof as efflux pump inhibitor to anti-microbial

The invention discloses a disubstituted bicyclic derivative and application thereof as an efflux pump inhibitor to anti-microbial. It is proved by experiments that the disubstituted bicyclic derivative has a good inhibition function on multidrug-resistant bacteria carrying an AcrB efflux pump and can effectively recover or enhance antibacterial efficiency of existing antibiotics. The chemical structural formula of the disubstituted bicyclic derivative is as shown in a formula (I) (the formula can be seen in specification), and R1, R2, X, Y, Z and W are as defined in the specification.

Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase

A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent,

Substituent-induced regioselective hydroxylation of the aromatic C-H bond on naphthalene with metachloroperbenzoic acid catalyzed by F20TPPMnCl

The regioselective hydroxylation of the aromatic C-H bond on a series of naphthalenes with different β-substituent R (R = H, Me, Et, i-Pr, OMe, COOH, Br, etc.) was studied, and the substituent effect on the regioselectivity was investigated. The electron-donating substituent afforded the aromatic C-H bond hydroxylation at the 1α position with more than 80% selectivity, while the electron-withdrawing substituent afforded the aromatic C-H bond hydroxylation at the 4α position with more than 60% selectivity of β-substituted naphthalene hydroxylated with metachloroperbenzoic acid catalyzed by tetrakis(pentafluorophenyl)porphyrin manganese(III) chloride. The research showed that the steric and electronic effects of the substituent appeared to play a significant role in determining the regioselectivity, and the electronic effect was of more importance than the steric effect of the substituent in the current situation. The studies may provide additional proofs for the stepwise mechanism of the aromatic C-H bond hydroxylation through a cationic intermediate. Copyright