656801-27-3Relevant academic research and scientific papers
PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES
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Page/Page column 36; 37, (2015/03/28)
The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analogue of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.
SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF
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Paragraph 0587-0588; 0635-0636, (2015/02/25)
Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.
Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents
Wang, Limin,Qu, Wenchao,Lieberman, Brian,Ploessl, Karl,Kung, Hank F.
scheme or table, p. 3482 - 3485 (2010/08/22)
Three new 18F labeled fluoroalkyl tyrosine derivatives, O-(2-[18F]fluoroethyl)-α-methyltyrosine (FEMT, [ 18F]2), O-(2-[18F]fluoroethyl)-2-l-azatyrosine (FEAT, [18F]3), O-(2-[18F]fluoroethyl
Efficient large-scale synthesis of Boc-L-azatyrosine
Germain, Herve,Harris, Craig S.,Renaud, Fabrice,Warin, Nicolas
experimental part, p. 523 - 530 (2009/06/20)
A rapid and convenient process for the synthesis of Boc-L-azatyrosine is described from commercially available Boc-β-iodo-Ala-OMe. Copyright Taylor & Francis Group, LLC.
L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
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Page/Page column 149-151, (2008/12/07)
The present invention relates to compounds of the formula (I) that inhibit of a5bl function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufac
L-ALANINE DERIVATIVES
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Page/Page column 86, (2008/06/13)
The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5b1 and also that exhibit appropriate selectivity profile(s) against other integrins.
Preparation of enantiomerically pure pyridyl amino acids from serine.
Tabanella, Stefania,Valancogne, Ingrid,Jackson, Richard F W
, p. 4254 - 4261 (2007/10/03)
A range of substituted pyridyl amino acids have been prepared by palladium catalysed cross-coupling of serine-derived organozinc reagents with differently substituted halopyridines. Following this procedure a DMAP analogue has been synthesised and used as
