656803-51-9Relevant academic research and scientific papers
Pyrimidopyridone compounds having antitumor activity as well as preparation method and application of pyrimidopyridone compounds
-
Paragraph 0086-0088, (2019/08/20)
The invention discloses pyrimidopyridone compounds having antitumor activity as well as a preparation method and application of the pyrimidopyridone compounds. The invention particularly discloses thedeuterated pyrimidopyridone compounds represented by a
Functionalized Helical β-Peptoids
Wellh?fer, Isabelle,Frydenvang, Karla,Kotesova, Simona,Christiansen, Andreas M.,Laursen, Jonas S.,Olsen, Christian A.
, p. 3762 - 3779 (2019/05/01)
Peptidomimetic foldamers adopting well-defined three-dimensional structures while being stable toward proteolysis are of interest in biomedical research, chemical biology, and biomimetic materials science. Despite their backbone flexibility, β-peptoids containing N-(S)-1-(1-naphthyl)ethyl (Ns1npe) side chains can fold into unique triangular prism-shaped helices. We report herein the successful introduction of amino groups onto robustly folded β-peptoid helices by construction and incorporation of novel chiral building blocks. This is the first example of an X-ray crystal structure of a linear β-peptoid containing more than one type of side chain. We thus present a unique foldamer design comprising a robustly folded core with functionalized side chains protruding perpendicular to the helical axis to provide a highly predictable display of functional groups. This work paves the way for development of β-peptoid foldamers with a desired function, such as catalytic properties or as scaffolds enabling polyvalent display.
NEW ANTIBACTERIAL COMPOUNDS
-
Page/Page column 59-60, (2016/07/05)
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.
5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
-
Paragraph 0784, (2015/12/05)
Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
Design and synthesis of novel sulfonamide-containing bradykinin hB 2 receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine
Fincham, Christopher I.,Bressan, Alessandro,D'Andrea, Piero,Ettorre, Alessandro,Giuliani, Sandro,Mauro, Sandro,Meini, Stefania,Paris, Marielle,Quartara, Laura,Rossi, Cristina,Squarcia, Antonella,Valenti, Claudio,Daniela, Fattori,Maggi, Carlo Alberto
supporting information; experimental part, p. 2091 - 2100 (2012/05/05)
A series of α,α-cycloalkylglycine sulfonamide compounds of general formula 1 has previously been identified by our group as selective human B2(hB2) receptor antagonists. Here we report the in vitro and in vivo BK antagonist activity
