656821-45-3Relevant academic research and scientific papers
Palladium-catalyzed intermolecular alkene carboacylation via ester C-O bond activation
Banovetz, Haley K.,Vickerman, Kevin L.,David, Colton M.,Alkan, Melisa,Stanley, Levi M.
supporting information, p. 3507 - 3512 (2021/05/10)
We report palladium-catalyzed intermolecular carboacylation of alkenes with ester electrophiles and tetraarylborate nucleophiles. Bicyclic alkenes react with a variety of pentafluorophenyl benzoate and alkanoate esters and sodium tetraarylborates to form ketone products in ≤99% yields. These reactions occur in the absence of a directing group and demonstrate esters are competent acyl electrophiles for intermolecular alkene carboacylation reactions.
Total synthesis of (±)-nicolaioidesin B via a highly regio- and diastereoselective Diels-Alder reaction
Pigott, Adam J.,Lepage, Romain J.,White, Jonathan M.,Coster, Mark J.
supporting information, p. 6864 - 6867 (2015/01/16)
The total synthesis of (±)-nicolaioidesin B, a natural product that shows preferential cytotoxicity against pancreatic cancer cells under nutrient starvation conditions, is achieved. The key step is a thermally-induced, highly regio- and diastereoselectiv
Convenient syntheses of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers
Babadzhanova,Kirij,Yagupolskii,Tyrra,Naumann
, p. 1813 - 1819 (2007/10/03)
A new convenient synthetic procedure to obtain various 1,1,1,3,3,3- hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers has been worked out starting from anhydrides or activated esters of carboxylic acids and trimethyl(trifluoromethyl)silane in the presence of tetramethylammonium fluoride. Conditions for the selective formation of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols as well as the trimethylsilyl derivatives have been found.
