656825-40-0

Basic information

• Product Name: (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol
• Synonyms: (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol
• CAS NO: 656825-40-0
• Molecular Weight: 266.337
• Mol File: 656825-40-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol(656825-40-0)
• EPA Substance Registry System: (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol(656825-40-0)

Safety Data

• Hazardous Substances Data: 656825-40-0(Hazardous Substances Data)

Upstream product

• 127665-77-4 (E)-5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-en-1-ol 
• 116003-84-0 (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol 
• 162473-68-9 methyl 5-(tert-butyldiphenylsilyl)oxy-2-pentenoate 

Downstream Products

• 34371-14-7 2-deoxy-D-ribonolactone 
• 91879-31-1 3-O-benzyl-2-deoxy-D-ribonolactone 

Relevant articles and documents

Enantioselective Synthesis and Biological Activity of (3S,4R)- and (3S,4S)-3-Hydroxy-4-hydroxymethyl-4-butanolides in Relation to PGE2

Compounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [3H]-PGE2 binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE 2. Compound 9 increases c-fos mRNA level as does PGE2 and antagonizes TPA-induced terminal differentiation.