656833-94-2Relevant academic research and scientific papers
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents
Zappala, Maria,Grasso, Silvana,Micale, Nicola,Zuccala, Giuseppe,Menniti, Frank S.,Ferreri, Guido,De Sarro, Giovambattista,De Micheli, Carlo
, p. 4427 - 4430 (2007/10/03)
A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.
