6571-51-3

Usage

Uses

Used in Organic Chemistry Research and Synthesis:
1,11-Dioxa[11]paracyclophane is utilized as a key intermediate in the synthesis of various organic compounds due to its unique structure and reactivity, contributing to the advancement of organic chemistry.
Used in Materials Science:
In the field of materials science, 1,11-Dioxa[11]paracyclophane is employed as a building block for the development of novel molecular architectures, leveraging its structural properties to create new materials with potential applications in various industries.
Used in Supramolecular Chemistry:
1,11-Dioxa[11]paracyclophane is used as a component in supramolecular chemistry to construct complex molecular systems through non-covalent interactions, which is crucial for the design of functional materials and molecular machines.
Used in Medicinal and Pharmaceutical Applications:
1,11-Dioxa[11]paracyclophane has been investigated for its potential biological activities and has shown promise in medicinal and pharmaceutical applications, potentially leading to the development of new drugs and therapeutic agents.

Upstream product

• 4549-33-1 1,9-Dibromononane 
• 123-31-9 hydroquinone 
• 132568-33-3 p-hydroxyphenyl 9-bromononyl ether 

Downstream Products

• 7065-80-7 (rp)-1,11-dioxa-[11]paracyclophane-13-carboxylic acid 

Relevant academic research and scientific papers

Enantioselective synthesis of planar-chiral 1, n -dioxa[ n ]paracyclophanes via catalytic asymmetric ortho -Lithiation

Figure presented Highly enantioselective ortho-lithiation and dilithiation of 1,n-dioxa[n]paracyclophanes were realized with the use of sec-butyllithium and a catalytic or stoichiometric amount of sparteine. Quenching with various electrophiles, such as i

Determination of the rotational energy barrier of planar-chiral cyclophanes using dynamic enantioselective gas chromatography and computer simulation

We synthesized numerous new monosubstituted dioxa[11]-paracyclophanes, which are planar-chiral atropisomers due to the hindered rotation of the bridge about the aromatic plane, and we were able to resolve the enantiomers of these compounds by enantioselective gas chromatography with selectively modified cyclodextrins as chiral stationary phases in polysiloxane solution. As a consequence of the competition between enantiomeric resolution and enantiomerization (interconversion) during the gas chromatographic process, coalescence phenomena or formation of plateaus between the peaks of both enantiomers are observable. The combination of these dynamic gas chromatographic investigations with computer simulation of elution profiles allows the facile and precise determination of the energy barrier of the enantiomerization reaction and the elucidation of the influence of substituents on the energy barrier. VCH Verlagsgesellschaft mbH, 1996.