657405-47-5Relevant articles and documents
Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitor
Courtney, Stephen M.,Hay, Philip A.,Buck, Richard T.,Colville, Claire S.,Phillips, David J.,Scopes, David I.C.,Pollard, Faye C.,Page, Martin J.,Bennett, James M.,Hircock, Margaret L.,McKenzie, Edward A.,Bhaman, Maina,Felix, Robert,Stubberfield, Colin R.,Turner, Paul R.
, p. 2295 - 2299 (2007/10/03)
Using a furanylthiazole acetic acid as a starting point, a novel series of benzoxazol-5-yl acetic acid derivatives have been identified as heparanase inhibitors. Several compounds possess an IC50 of ~200 nM against heparanase, for example, tran