657405-49-7

Upstream product

• 121-87-9 2-Chloro-4-nitroaniline 
• 657405-46-4 2-bromo-1-[5-(2-chloro-4-nitro-phenyl)-furan-2-yl]-ethanone 
• 657405-45-3 1-[5-(2-chloro-4-nitro-phenyl)-furan-2-yl]-ethanone 
• 657405-48-6 {4-[5-(4-amino-2-chloro-phenyl)-furan-2-yl]-thiazol-2-yl}-acetic acid methyl ester 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 657405-47-5 {4-[5-(2-chloro-4-nitro-phenyl)-furan-2-yl]-thiazol-2-yl}-acetic acid methyl ester 

Relevant academic research and scientific papers

Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitor

Using a furanylthiazole acetic acid as a starting point, a novel series of benzoxazol-5-yl acetic acid derivatives have been identified as heparanase inhibitors. Several compounds possess an IC50 of ～200 nM against heparanase, for example, tran

FURANTHIAZOLE DERIVATIVES AS HEPARANASE INHIBITORS

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: (I) wherein the groups Q, R2, R3, R4 and R5 represent various substituent groups, and their use as inhibitors of heparanase.