65746-45-4Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS
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Paragraph 0442; 0446, (2020/07/16)
The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
LIPOXYGENASE INHIBITING COMPOUNDS
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, (2008/06/13)
Certain N-aryl, N-heteroaryl-, N-arylalkyl-, N-heteroarylalkyl-, N-arylcyclopropyl- and N-heteroaryl-cyclo-propyl-N'-hydroxyurea compounds are inhibitors of lipoxygenase enzyme activity and are thus useful agents in treating disease states such as asthma,
Selective Conversion of Benzylic C-H Bonds to an Amine Function by Oxidative Nucleophilic Substitution
Guy, Alain,Lemor, Alain,Doussot, Joel,Lemaire, Marc
, p. 900 - 902 (2007/10/02)
The benzylic proton of alkylarenes 1 was replaced by an azido group in one step by reaction with trimethylsilyl azide or hydrazoic acid in chloroform in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).The 1-arylalkyl azides 2 were reduced to amines 3, which were characterized as their hydrochlorides 4.
