6575-10-6

Basic information

• Product Name: 2-CHLORO-6-METHOXYBENZONITRILE
• Synonyms: 2-CHLORO-6-METHOXYBENZONITRILE;Benzonitrile, 2-chloro-6-methoxy-;2-Chloro-6-methoxybenzonitrile,97%;2-Methoxy-6-chlorobenzonitrile;6-Chloro-o-anisonitrile
• CAS NO: 6575-10-6
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59
• EINECS: 229-500-9
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 6575-10-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 294.7 °C at 760 mmHg
• Flash Point: 132 °C
• Appearance: /
• Density: 1.25 g/cm³
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: 2-CHLORO-6-METHOXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHOXYBENZONITRILE(6575-10-6)
• EPA Substance Registry System: 2-CHLORO-6-METHOXYBENZONITRILE(6575-10-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6575-10-6(Hazardous Substances Data)

Usage

Chemical Properties

White Needles

Uses

2-Chloro-6-methoxybenzonitrile (cas# 6575-10-6) is a compound useful in organic synthesis.

InChI:InChI=1S/C8H6ClNO/c1-11-8-4-2-3-7(9)6(8)5-10/h2-4H,1H3

Upstream product

• 668-45-1 2-chloro-6-fluorobenzonitrile 
• 124-41-4 sodium methylate 
• 89999-90-6 3-chloro-2-cyanophenol 
• 74-88-4 methyl iodide 
• 5472-99-1 3-chloro-2-nitroanisole 
• 158966-62-2 6-chloro-o-anisidine 

Downstream Products

• 1638631-82-9 2-methoxy-6-(3-methoxy-4-methylphenylamino)benzonitrile 
• 104778-01-0 Murrayaline-A 
• 139726-42-4 murrayaline B 
• 1638631-87-4 7-benzyloxy-2-methoxy-6-methylcarbazole-1-carbonitrile 
• 1638631-88-5 7-benzyloxy-2-methoxy-6-methylcarbazole-1-carbaldehyde 
• 1638631-84-1 2-methoxy-6-[4-methyl-3-(triisopropylsilyloxy)phenylamino]benzonitrile 
• 1638631-89-6 2-methoxy-6-[3-(triisopropylsilyloxy)phenylamino]benzonitrile 
• 1638631-92-1 methyl 4-[(2-cyano-3-methoxyphenyl)amino]-2-(triisopropylsilyloxy)benzoate 
• 1638631-86-3 2-[3-(benzyloxy)-4-methylphenylamino]-6-methoxybenzonitrile 
• 927902-53-2 (2-chloro-6-methoxyphenyl)methanamine 
• 881883-32-5 1-(2-Chloro-6-methoxy-phenyl)-ethanone 
• 55736-04-4 6’-chloro-2’-hydroxyacetophenone 
• 1354928-57-6 C₁₇H₁₁ClO₄ 
• 1354928-51-0 C₁₇H₁₁ClO₄ 

Relevant articles and documents

Exploiting Imine Photochemistry for Masked N-Centered Radical Reactivity

This report details the development of a masked N-centered radical strategy that harvests the energy of light to drive the conversion of cyclopropylimines to 1-aminonorbornanes. This process employs the N-centered radical character of a photoexcited imine to facilitate the homolytic fragmentation of the cyclopropane ring and the subsequent radical cyclization sequence that forms two new C?C bonds en route to the norbornane core. Achieving bond-forming reactivity as a function of the N-centered radical character of an excited state Schiff base is unique, requiring only violet light in this instance. This methodology operates in continuous flow, enhancing the potential to translate beyond the academic sector. The operational simplicity of this photochemical process and the structural novelty of the (hetero)aryl-fused 1-aminonorbornane products are anticipated to provide a valuable addition to discovery efforts in pharmaceutical and agrochemical industries.

Palladium(II)-catalyzed synthesis of the formylcarbazole alkaloids murrayaline A-C, 7-methoxymukonal, and 7-methoxy-o-methylmukonal

We describe the synthesis of the naturally occurring 2,7-dioxygenated formylcarbazole alkaloids 7-methoxymukonal, 7-methoxy-O-methylmukonal, and the murrayalines A-C. The carbazole framework was constructed by a Buchwald-Hartwig amination and a subsequent palladium(II)-catalyzed oxidative cyclization. We describe the synthesis of the naturally occurring 2,7-dioxygenated formylcarbazole alkaloids 7-methoxymukonal, 7-methoxy-O-methylmukonal, and the murrayalines A-C. The carbazole framework was constructed by a Buchwald-Hartwig amination and a subsequent palladium(II)-catalyzed oxidative cyclization. Copyright