6576-04-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(3-fluorophenyl)-2-(4-pyridinyl)is utilized as a building block for the synthesis of various drugs and bioactive molecules. Its presence in the synthesis process is crucial for creating compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the realm of organic synthesis, Ethanone, 1-(3-fluorophenyl)-2-(4-pyridinyl)serves as a key intermediate, facilitating the creation of a wide array of chemical entities with different functional groups and properties.
Used in Medicinal Chemistry:
Ethanone, 1-(3-fluorophenyl)-2-(4-pyridinyl)is employed in medicinal chemistry for its potential to contribute to the development of new pharmaceuticals. Its unique structure allows for the exploration of novel drug candidates with improved efficacy and selectivity.
Used in Research and Development:
Ethanone, 1-(3-fluorophenyl)-2-(4-pyridinyl)is also used in research and development settings to study its pharmacological properties and to understand its interactions with biological targets, which can lead to the discovery of new therapeutic agents.

Upstream product

• 325770-39-6 1-(3-fluorobenzoyl)-2-methylaziridine 
• 108-89-4 picoline 
• 451-02-5 ethyl 3-fluorobenzoate 
• 1711-07-5 3-fluorobenzoyl chloride 

Downstream Products

• 1173171-57-7 1-(3-fluorophenyl)-2-(pyridin-4-yl)ethanone O-methyl oxime 
• 925678-06-4 1-(3-fluorophenyl)-2-pyridin-4-ylethane-1,2-dione 
• 861804-67-3 4-[5-(3-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 325769-21-9 [4-(3-fluorophenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine 
• 861804-91-3 4-[4-(3-fluoro-phenyl)-4-oxo-3-pyridin-4-yl-butyryl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS

The present invention provides a compound of formula (I) wherein: A represents an optionally substituted monocyclic or polycyclic aryl or heteroaryl group B represents an optionally substituted monocyclic nitrogen-containing heteroaryl group ; and either a) R1 and R2 represent hydrogen or specified substituents, or b) R2, R1 and the -NH- group to which R1 is attached, form a moiety selected from the moiety of formulae (IIa) and (IIb): (IIa) These compounds are useful as antagonists of the A2B receptor, for instance in the treatment of asthma.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors

A novel series of 4-phenyl-5-pyridyl-1,3-thiazole analogues possessing potent in vitro inhibitory activity against p38 mitogen-activated protein kinase and the release of tumor necrosis factor-α (TNF-α) from human monocytic THP-1 cells stimulated by lipopolysaccharide has been identified. Subsequent structure-activity relationship (SAR) studies and optimization for absorption, distribution, metabolism, and elimination (ADME) profiles led to the identification of compounds 7g and 10b as orally active lead candidates that block the in vivo production of proinflammatory cytokine (TNF-α). In pharmacokinetic studies, compound 10b showed good oral administration in mice and demonstrated significant in vivo anti-inflammatory activity in an anti-collagen monoclonal antibody-induced arthritis mouse model (minimum effective dose (MED)=30 mg/kg). Further elucidation of this class of compounds may provide novel anti-inflammatory agents, such as anti-rheumatoid arthritis drugs.

Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in vivo activities. The most potent