65776-11-6

Basic information

• Product Name: L-Cysteine, N-[(4-methoxyphenyl)methyl]-
• CAS NO: 65776-11-6
• Molecular Formula: C11H15NO3S
• Molecular Weight: 241.311
• Mol File: 65776-11-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Cysteine, N-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cysteine, N-[(4-methoxyphenyl)methyl]-(65776-11-6)
• EPA Substance Registry System: L-Cysteine, N-[(4-methoxyphenyl)methyl]-(65776-11-6)

Safety Data

• Hazardous Substances Data: 65776-11-6(Hazardous Substances Data)

Upstream product

• 222404-25-3 (R)-2-(4-Methoxy-phenyl)-thiazolidine-4-carboxylic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 209741-90-2 (R)-3-[(R)-2-Carboxy-2-(4-methoxy-benzylamino)-ethyldisulfanyl]-2-(4-methoxy-benzylamino)-propionic acid 

Downstream Products

• 139944-38-0 (-)-3-(4-methoxybenzyl)-2-oxo-thiazolidine-4-carboxylic acid 
• 117389-93-2 3-(4-methoxybenzyl)-4-methoxycarbonyl-1,3-thiazolidine-2-thione 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES

The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to

Novel methods for the synthesis of 3-arylmethyl-4-thiazolidine carboxylic acid-2-thiones and their methyl esters

Reductive amination, using benzaldehyde derivatives and sodium borohydride, on L-cystine yields N,N'-di (arylmethyl) cystines 7a-c which can be converted into N, N'-di(arylmethyl) cystine dimethyl esters 8a-c by esterification. The reductive reaction by zinc, hydrochloric acid and methanol on the derivatives 7 and 8 yields the thiols 4a-c and 5a-c, respectively which on reaction with CS2 or EtOCS2K are further converted into 3-arylmethyl-4-thiazolidine carboxylic acid-2-thiones 1a-c and their methyl esters 2a-c. Compounds 2a-c are also produced by esterification of 1a-c. Fewer reaction steps and higher yields are the advantages of these methods.