65783-00-8

Upstream product

• 65548-02-9 (+/-)-ethyl cyano(2-nitrophenyl)acetate 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 69642-00-8 α-methyl-o-nitrobenzyl bromide 
• 88975-16-0 Cyano-methyl-(2-nitro-phenyl)-acetic acid ethyl ester 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 88975-17-1 2-(2-aminophenyl)propionitrile 
• 56355-31-8 2-[4-(methyl-thiazol-2-yl-amino)-phenyl]-propionic acid 
• 88975-44-4 2-(2-Hydroxy-phenyl)-propionitrile 
• 88975-27-3 2-(2-methylaminophenyl)propionitrile 
• 88975-94-4 2-(2-Cyanato-phenyl)-propionitrile 
• 88976-04-9 N-[2-(Cyano-methyl-methyl)-phenyl]-2,2,2-trifluoro-acetamide 
• 88975-49-9 2-<2-(2-thiazolylamino)phenyl>propionic acid 
• 88975-97-7 2-<2-(2-thiazolyloxy)phenyl>propionic acid 
• 88975-79-5 2-<2-(N-methyl-N-thiazol-2-ylamino)phenyl>propionic acid 
• 88975-59-1 1-Benzoyl-3-[2-(cyano-methyl-methyl)-phenyl]-thiourea 
• 88975-74-0 3-Benzoyl-1-[2-(cyano-methyl-methyl)-phenyl]-1-methyl-thiourea 
• 25798-61-2 ortho-nitroso acetophenone 
• 83-34-1 3-Methylindole 

Relevant academic research and scientific papers

Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.

Enantioselective synthesis of (R)-2-arylpropanenitriles catalysed by ene-reductases in aqueous media and in biphasic ionic liquid-water systems

The enantioselective reduction of α-methylene nitrile derivatives catalysed by ene-reductases affords the corresponding (R)-2-arylpropanenitriles with high conversion values. The reaction is investigated either in aqueous medium (with an organic cosolvent or by loading the substrate onto hydrophobic resins) or in a biphasic ionic liquid-water system. The use of ionic liquids, herein with isolated ene-reductases, is found to improve the work-up and the substrate recovery method. The synthetic manipulation of the final chiral nitrile derivatives indicates how this biocatalysed method can be exploited for the preparation of a wide range of chiral compounds.

A caged cyanide

A photoactivatable caged cyanide, 1-(2-nitrophenyl)ethyl (NPE) cyanide, was synthesized, which upon irradiation in the near UV releases cyanide. It is demonstrated that the compound can be used to induce formation of the Fe III-CN- complex in the heme protein nitrophorin 4 from Rhodnius prolixus.