65548-02-9

Basic information

• Product Name: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE
• Synonyms: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE;ETHYL CYANO(2-NITROPHENYL)ACETATE;Cyano(2-nitrophenyl)acetic Acid Ethyl Ester;α-Cyano-2-nitro-benzeneacetic Acid Ethyl Ester;ETHYL CYANO(2-NITROPHENYL)ACETATE(WX191716)
• CAS NO: 65548-02-9
• Molecular Formula: C₁₁H₁₀N₂O₄
• Molecular Weight: 234.21
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 65548-02-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 49-51°C
• Boiling Point: 402°C at 760 mmHg
• Flash Point: 196.9°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 1.13E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE(65548-02-9)
• EPA Substance Registry System: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE(65548-02-9)

Safety Data

• Hazardous Substances Data: 65548-02-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Oil

Uses

Ethyl Cyano(2-nitrophenyl)acetate (cas# 65548-02-9) is a compound useful in organic synthesis.

InChI:InChI=1/C11H10N2O4/c1-2-17-11(14)9(7-12)8-5-3-4-6-10(8)13(15)16/h3-6,9H,2H2,1H3/t9-/m0/s1

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 528-29-0 1,2-Dinitrobenzene 
• 577-19-5 2-nitrophenyl bromide 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 345930-97-4 Cyano-(2-{[1-phenyl-meth-(E)-ylidene]-amino}-phenyl)-acetic acid ethyl ester 
• 5719-08-4 4-chloro-1H-pyrimido[4,5-b]indole 
• 1403589-26-3 4-chloro-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-pyrimido[4,5-b]indole 
• 1403589-33-2 4-(furan-2-yl)-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-9H-pyrimido[4,5-b]indole 
• 65547-91-3 2-amino-1-hydroxy-indole-3-carboxylic acid ethyl ester 
• 160292-68-2 (N-Hydroxycarbamimidoyl)-(2-nitro-phenyl)-acetic acid ethyl ester 
• 154373-03-2 5-Amino-4-(2-nitro-phenyl)-1H-pyrazol-3-ol 
• 344331-74-4 (2-Amino-phenyl)-cyano-acetic acid ethyl ester 

Relevant articles and documents

Formal Total Synthesis of (±)-Strictamine by [2,3]-Sigmatropic Stevens Rearrangements

To date, more than 100 congeners of the akuammiline alkaloid family have been isolated. Their signature structural element is a methanoquinolizidine moiety, a cage-like scaffold structurally related to adamantane. The structural variations of the family members originate from oxidative processes that mostly trigger rearrangements of the methanoquinolizidine motif. The family of the akuammiline alkaloids is best represented by strictamine. It bears the least functionalized carbon skeleton of all family members without lacking the signature structural motifs. Herein, we report the formal synthesis of strictamine through a Stevens [2,3]-sigmatropic rearrangement as a key step and the synthetic pitfalls related with its synthesis.

Formal total synthesis of (±)-strictamine-the [2,3]-Stevens rearrangement for construction of octahydro-2: H -2,8-methanoquinolizines

For decades, akuammiline alkaloids have attracted synthetic chemists due to their intriguing molecular architecture. Among the different structural elements embedded in their carboskeleton, the methanoquinolizidine system constitutes the signature structu

HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF

The present invention relates to a novel hydroxamate derivatives, more specifically, to novel hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC), isomers thereof, pharmaceutically acceptable salts thereof, hydrates or solvates thereof, use for preparing pharmaceutical compositions, pharmaceutical compositions comprising the same, treatment method using said composition, and a preparing method of novel hydroxamate derivatives. The novel selective hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC) compositions can be used for treatment of inflammatory disease, rheumatoid arthritis, or degenerative disease.