65795-63-3Relevant academic research and scientific papers
COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY
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Page/Page column 13; 16, (2022/01/12)
In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of various bacterial infections and/or other diseases. In some embodiments, for example, compounds of Formula (I) and/or salts thereof are described herein.
Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists
Ahn, Ho-Sam,Arik, Leyla,Boykow, George,Burnett, Duane A.,Caplen, Mary Ann,Czarniecki, Michael,Domalski, Martin S.,Foster, Carolyn,Manna, Mahua,Stamford, Andrew W.,Wu, Yusheng
, p. 2073 - 2078 (2007/10/03)
A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor. Analogs were prepared to study the structure-activity relationships of substitution at the N1, N3, and N7 positions of the heterocycle. Compounds 4e and 4f have been identified with IC50's of 56 and 52 nM, respectively.
