658-75-3

Upstream product

• 371-41-5 4-Fluorophenol 
• 407-25-0 trifluoroacetic anhydride 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 2923-16-2 potassium trifluoroacetate 
• 1765-93-1 4-fluoroboronic acid 
• 214360-58-4 2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 456-22-4 4-Fluorobenzoic acid 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 402-44-8 4-Fluorobenzotrifluoride 
• 352-67-0 1-fluoro-4-(trifluoromethoxy)benzene 
• 371-41-5 4-Fluorophenol 
• 76-05-1 trifluoroacetic acid 

Relevant academic research and scientific papers

Decarboxylative Hydroxylation of Benzoic Acids

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.

Copper-Mediated Functionalization of Aryl Trifluoroborates

This paper describes the Cu(OTf)2-mediated coupling of aryl and heteroaryl trifluoroborates with tetrabutylammonium or alkali metal salts to form C-O, C-N, and C-halogen bonds. The reactions proceed under mild conditions (often room temperature over 16 hours) with carboxylate, halide, and azide salts, all nucleophiles that have been underrepresented in the copper cross-coupling literature. Preliminary results show that copper salts bearing weakly coordinating X-type ligands are essential for enabling these transformations to proceed under mild conditions.