658084-23-2 Usage
Uses
Used in Cancer Research and Treatment:
SU 11274 is used as a competitive inhibitor of Met kinase activity for targeting dysregulated c-Met, which occurs in many types of cancer. By inhibiting Met kinase activity, SU 11274 can help in the development of cancer therapies and the study of c-Met's role in tumor growth and progression.
Biochem/physiol Actions
SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2
references
[1] wang x1, le p, liang c, chan j, kiewlich d, miller t, harris d, sun l, rice a, vasile s, blake ra, howlett ar, patel n, mcmahon g, lipson ke. potent and selective inhibitors of the met [hepatocyte growth factor/scatter factor (hgf/sf) receptor] tyrosine kinase block hgf/sf-induced tumor cell growth and invasion. mol cancer ther. 2003 nov;2(11):1085-92.[2] leiser d1, pochon b1, blank-liss w1, francica p1, glück aa1, aebersold dm1, zimmer y1, medová m2. targeting of the met receptor tyrosine kinase by small molecule inhibitors leads to met accumulation by impairing the receptor downregulation. febs lett. 2014 mar 3;588(5):653-8.
Check Digit Verification of cas no
The CAS Registry Mumber 658084-23-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,8,0,8 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 658084-23:
(8*6)+(7*5)+(6*8)+(5*0)+(4*8)+(3*4)+(2*2)+(1*3)=182
182 % 10 = 2
So 658084-23-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
