65825-13-0Relevant academic research and scientific papers
μ-Oxo-Dinuclear-Iron(III)-Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of Tertiary Alcohols
Horikawa, Rikiya,Fujimoto, Chika,Yazaki, Ryo,Ohshima, Takashi
, p. 12278 - 12281 (2016)
A highly chemoselective and reactive μ-oxo-dinuclear iron(III) salen catalyst for transesterification was developed. The developed iron complex catalyzed acylation of aliphatic amino alcohols with nearly perfect O-selectivity, even when using activated esters, for which chemoselectivity is more difficult to control. In addition, O-selective transesterification of aromatic amino alcohols was achieved for the first time. The high activity of the iron complex enabled the use of sterically congested tertiary alcohols, including unprecedented tert-butanol.
Fat trifluoro ethyl ester compound and preparation method thereof
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Paragraph 0027-0029; 0043, (2018/11/22)
The invention relates to a fat trifluoro ethyl ester compound and a preparation method thereof. The definition of the fat acid trifluoro ethyl ester compound is same with the definition in the claim.The preparation method comprises the following steps that under the low temperature condition, 2, 2, 2-trifluoroethylamine and tert-butyl nitrite are added into an organic solution with fatty acid dissolved in, and after uniformly stirring, the mixture reacts continuously at the indoor temperature, and a fatty acid trifluoro ethyl ester product can be obtained. The molar ratio among fat acid, 2, 2, 2-trifluoroethylamine and tert-butyl nitrite is 1:(1-2.5):(1-2.5). According to the preparation method, it is not necessary to add catalyst and other additives, and a target product can be obtained,the operation is simple, reaction conditions are mild, the cost is low, the yield is high, the method is environmentally friendly, the trifluoro ethyl ester compound of fat and drug molecule carboxylic acid can be obtained, and the application is wide.
