65826-94-0

Basic information

• Product Name: α-phenyl-2-amino-5-methoxyphenethyl alcohol
• Synonyms: α-phenyl-2-amino-5-methoxyphenethyl alcohol
• CAS NO: 65826-94-0
• Molecular Weight: 243.305
• Mol File: 65826-94-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α-phenyl-2-amino-5-methoxyphenethyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: α-phenyl-2-amino-5-methoxyphenethyl alcohol(65826-94-0)
• EPA Substance Registry System: α-phenyl-2-amino-5-methoxyphenethyl alcohol(65826-94-0)

Safety Data

• Hazardous Substances Data: 65826-94-0(Hazardous Substances Data)

Upstream product

• 109433-96-7 α-phenyl-5-methoxy-2-nitrophenethyl alcohol 
• 5367-32-8 5-methoxy-2-nitrotoluene 
• 100-52-7 benzaldehyde 

Downstream Products

• 1313843-85-4 4,5-dihydro-7-methoxy-2-(1-methylethyl)-4-phenyl-3,1-benzoxazepine 
• 1313843-86-5 2-(tert-butyl)-4,5-dihydro-7-methoxy-4-phenyl-3,1-benzoxazepine 
• 1313843-87-6 4,5-dihydro-7-methoxy-4-phenyl-2-(thiophen-2-yl)-3,1-benzoxazepine 
• 1313843-92-3 4,5-dihydro-7-methoxy-N,4-diphenyl-3,1-benzoxazepin-2-amine 
• 5883-96-5 5-methoxy-2-phenylindole 

Relevant articles and documents

One-pot synthesis of 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepines from 2-(2-Aminophenyl)-1-arylethanols via dehydration of the corresponding amides

An efficient method for the preparation of 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepine derivatives under mild conditions has been developed. The reaction of 2-(2-aminophenyl)ethanols 1 with acid chlorides in the presence of excess Et3N in THF at room temperature gave the corresponding N-acylated intermediates 2, which were dehydrated by treatment with POCl3 to give 2-substituted 4-aryl-4,5-dihydro-3,1- benzoxazepines 3 in a one-pot reaction.