65836-73-9Relevant academic research and scientific papers
Aggregation-induced emission behavior of a pH-controlled molecular shuttle based on a tetraphenylethene moiety
Han, Xie,Cao, Meijiao,Xu, Zhiqiang,Wu, Di,Chen, Zhao,Wu, Anxin,Liu, Sheng Hua,Yin, Jun
, p. 9767 - 9774 (2015/10/05)
Tetraphenylethene (TPE) with aggregation-induced emission (AIE) behavior as a popular backbone is applied widely in the construction of functional supramolecular systems. In this work, a TPE-based linear molecule having amide and amine units is synthesize
Chirality sensing and size discrimination of anions by macrotricyclic cyclen-disodium complexes
Ito, Hiroshi,Shinoda, Satoshi
, p. 238 - 241 (2015/02/19)
Two macrotricyclic ligands composed of two face-to-face octadentate metal chelates were synthesized. These cage-shaped disodium complexes had special recognition ability for various counter anions. Specific chiral dicarboxylates bound to the complexes within the cavity and exhibited chirality induction properties. For instance, N-Boc-Asp dianion strongly induced circular dichroism (CD) signals, but N-Boc-Glu dianion, which is one carbon longer, did not. Chirality on Na+: The first example of chirality sensing on Na+ was achieved by a macrotricyclic host composed of two octadentate cyclen-Na+ complexes. Chiral N-Boc-Asp dianions coordinated to the Na+ at the cavity, resulting in the chirality induction of the cage molecule, but N-Boc-Glu dianion, which is one carbon longer, did not.
Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor
Huynh, Tracey,Valant, Celine,Crosby, Ian T.,Sexton, Patrick M.,Christopoulos, Arthur,Capuano, Ben
, p. 8196 - 8200 (2013/11/06)
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library of putative M4 PAMs derived from VU0152100 and VU10005. These compounds investigate the pharmacological effects of previously identified methoxy and fluoro substituents, providing useful estimates of affinity (KB), cooperativity (αβ), and direct agonist properties (τB).
