65844-46-4

Upstream product

• 22955-78-8 methyl 6-methoxy-1-oxoindane-2-carboxylate 
• 64-19-7 acetic acid 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 58461-21-5 methyl 5-methoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate 

Downstream Products

• 136191-08-7 5-hydroxyindane-2-carboxylic acid 
• 1289563-68-3 methyl 5-phenylindane-2-carboxylate 
• 1289563-70-7 (5-phenylindan-2-yl)methanol 
• 1289563-73-0 5-phenylindane-2-carboxaldehyde 
• 1289563-76-3 oxazol-2-yl(5-phenylindan-2-yl)methanol 
• 1289563-78-5 2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)oxazole 
• 1289563-80-9 2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(tributylstannyl)oxazole 
• 1289563-82-1 2-((tert-butyldimethylsilyloxy)(5-phenylindan-2-yl)methyl)-5-(pyridin-2-yl)oxazole 
• 1289563-84-3 (5-phenylindan-2-yl)(5-(pyridin-2-yl)oxazol-2-yl)methanol 
• 1289563-86-5 Methyl 6-{2-[(tert-butyldimethylsilyloxy)-(5-phenylindan-2-yl)methyl]oxazol-5-yl}pyridine-2-carboxylate 
• 1289563-89-8 methyl 6-{2-[hydroxy-(5-phenylindan-2-yl)methyl]oxazol-5-yl}pyridine-2-carboxylate 
• 1289563-91-2 methyl 5-phenoxyindane-2-carboxylate 
• 1289563-94-5 (5-phenoxyindan-2-yl)methanol 
• 1289563-97-8 5-phenoxyindane-2-carboxaldehyde 

Relevant academic research and scientific papers

ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING

Compounds are disclosed that are effective in inhibition of fatty acid amide hydrolase, an enzyme responsible for catabolism of endogenous cannabinoids such as anandamide. The compounds are useful as analgesic compounds and as sleep-inducing compounds, that can be orally administered, and that can have a relatively long duration of effect. Methods of preparation of the compounds are also provided. The compounds are conformationally constrained analogs of heterocyclylketones such as oxazolylketones.

Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: Orally active, long-acting analgesics

A series of α-ketooxazoles containing conformational constraints in the C2 acyl side chain of 2 (OL-135) were examined as inhibitors of fatty acid amide hydrolase (FAAH). Only one of the two possible enantiomers displayed potent FAAH inhibition (S vs R en

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS

A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diastereomers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.