65845-73-0Relevant academic research and scientific papers
A Metal-Free Approach for Bronsted Acid Promoted C-H Alkylation of Heteroarenes with Alkyl Peroxides
Zeng, Yuehua,Qian, Bo,Li, Yajun,Bao, Hongli
, p. 3250 - 3256 (2018/06/08)
A metal-free protocol for Minisci C-H alkylation of heteroarenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of Bronsted acid has been demonstrated. A series of alkyl substituted heteroarenes were readily prepared by the C-H alkylation in moderate to good yields. A possible pathway involving the addition of alkyl radical to heterocycle followed by rearomatization is described.
Synthesis of Functionalized Quinolines through a Reaction of Amides and Alkynes Promoted by Triflic Anhydride/Pyridine
Li, Lian-Hua,Niu, Zhi-Jie,Liang, Yong-Min
supporting information, p. 15300 - 15304 (2017/10/20)
A concise, novel and flexible metal-free single step to synthesize functionalized quinolines is reported. Triflic anhydride-mediated (Tf2O) activation of amides is discussed in the presence of pyridine to offer strong electrophiles, thereby showcasing excellent productivity, high regio- and chemoselectivity, and widely tolerable substrates. This approach provides a straightforward and efficient way to construct azaheterocycle structures.
