65854-78-6 Usage
Description
OXAZEPAM-D5 is a benzodiazepine-based analytical reference material designed as an internal standard for the quantification of oxazepam by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). It is structurally similar to oxazepam, which is an active metabolite of diazepam, prazepam, and temazepam. OXAZEPAM-D5 plays a crucial role in forensic and research applications, particularly in the analysis of substances that modulate GABAA receptors, leading to inhibitory effects in the central nervous system.
Uses
Used in Forensic and Research Applications:
OXAZEPAM-D5 is used as an internal standard for the accurate quantification of oxazepam in various samples. This application is crucial for forensic investigations and research studies that require precise measurements of benzodiazepine compounds in biological or environmental samples.
Used in Pharmaceutical Analysis:
OXAZEPAM-D5 is used as a labeled oxazepam, serving as a reference for the development and validation of analytical methods in the pharmaceutical industry. Its use ensures the quality control and standardization of benzodiazepine-based medications, including anxiolytics, muscle relaxants, and anticonvulsants.
Used in GABAA Receptor Research:
OXAZEPAM-D5 is utilized as a ligand for the GABAA receptor benzodiazepine modulatory site. This application is vital for understanding the molecular mechanisms of benzodiazepines and their effects on the central nervous system. It aids researchers in developing new therapeutic agents targeting the GABAA receptor.
Used in Controlled Substance Monitoring:
As a controlled substance, OXAZEPAM-D5 is used in monitoring and regulating the distribution and use of depressant drugs. Its application helps in ensuring compliance with legal and regulatory standards, preventing misuse, and maintaining public health and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 65854-78-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,8,5 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 65854-78:
(7*6)+(6*5)+(5*8)+(4*5)+(3*4)+(2*7)+(1*8)=166
166 % 10 = 6
So 65854-78-6 is a valid CAS Registry Number.
65854-78-6Relevant articles and documents
Preparation method of stable isotope labeled oxazepam internal standard reagent
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Paragraph 0060-0062, (2021/10/27)
The invention relates to a preparation method of a stable isotope labeled oxazepam internal standard reagent for monitoring the blood concentration of clinical treatment drugs, and belongs to the field of research and development of standard substances for monitoring clinical treatment drugs. The stable isotope labeled oxazepam is obtained by taking stable isotope labeled phenylboronic acid as a raw material through catalytic addition, acylation, cyclization, acetylation, hydrolysis and final separation and purification. The process has the advantages that raw materials needed for synthesis are simple and easy to obtain, reaction conditions are mild, the chemical purity of the target product stable isotope labeled oxazepam can reach 98% or above, the isotope abundance can reach 98% or above, and the preparation method can meet the technical requirements of a stable isotope labeled internal standard reagent needed by a clinical drug monitoring liquid chromatography-tandem mass spectrometry method.
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