65862-01-3

Upstream product

• 30494-14-5 methyl 3-methyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carboxylate 
• 138732-35-1 t-butyl 3-methylbicyclo<1.1.1>pentane-1-carboxylate 
• 30493-92-6 methyl 3-methylbicyclo<1.1.0>butane-1-carboxylate 
• 124-38-9 carbon dioxide 
• 136399-10-5 1-iodo-3-methylbicyclo<1.1.1>pentane 
• 35634-10-7 [1.1.1]propellane 

Downstream Products

• 83249-16-5 1-acetyl-3-methylbicyclo<1.1.1>pentane 
• 137741-15-2 1-bromo-3-methylbicyclo<1.1.1>pentane 
• 83249-20-1 4-Nitro-benzoic acid 1-methyl-1-(3-methyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester 
• 796963-34-3 3-methylbicyclo[1.1.1]pentan-1-amine hydrochloride 

Relevant academic research and scientific papers

BICYCLIC COMPOUNDS

Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.

Synthesis of Some Bridgehead-Bridgehead-Disubstituted Bicyclopentanes

The synthesis of a wide variety of 1,3-disubstituted bicyclopentanes is described, with particular emphasis on the generation of a series of 3-X-substituted bicyclopentyl bromides required for solvolytic studies.Functional group manipulation at the bridgehead was readily accomplished in the majority of cases by radical processes; in some instances, transformations were effected via carbanionic-type intermediates.

Polar Substituent Effects in 1,3-Disubstituted Bicyclopentanes

The pKa's of eight 3-substituted bicyclopentanecarboxylic acids have been measured and found to correlate well with ?I constants.The value of ρI (2.23 +/- 0.12) is large but not large enough to propose any special perturbation of normal field-inductive effects by the close proximity (about 1.88 Ae) of the bridgehead carbons.Also determined were the products and rates of solvolyses of the p-nitrobenzoates of three 3-substituted 1-pentanes.The products were primarily unrearranged, and the rates again showed no surprisingsubstituent effects.A practical synthesis of 1,3-disubstituted bicyclopentanes has been developed and is described.