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658701-59-8

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658701-59-8 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 658701-59-8 differently. You can refer to the following data:
1. 6,10-Dihydroxy Buspirone is an Impurity formed during the preparation of Buspirone metabolites. Also, it is derived from Buspirone (B689855), which is a non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist.
2. Impurity formed during the preparation of Buspirone metabolites.

Check Digit Verification of cas no

The CAS Registry Mumber 658701-59-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,8,7,0 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 658701-59:
(8*6)+(7*5)+(6*8)+(5*7)+(4*0)+(3*1)+(2*5)+(1*9)=188
188 % 10 = 8
So 658701-59-8 is a valid CAS Registry Number.

658701-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,10-Dihydroxy Buspirone

1.2 Other means of identification

Product number -
Other names 6,10-dihydroxy-8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:658701-59-8 SDS

658701-59-8Upstream product

658701-59-8Downstream Products

658701-59-8Relevant articles and documents

Development of a safe and scalable oxidation process for the preparation of 6-hydroxybuspirone: Application of in-line monitoring for process ruggedness and product quality

Watson, Daniel J.,Dowdy, Eric D.,DePue, Jeffrey S.,Kotnis, Atul S.,Leung, Simon,O'Reilly, Brian C.

, p. 616 - 623 (2004)

The development of a safe and scalable oxidation process for the hydroxylation of the azapirone psychotropic agent buspirone (1) to furnish 6-hydroxybuspirone (2) is described. A mechanistic understanding of how key process factors affected product quality led to the successful application of FTIR as a process analytical technology (PAT) tool. This enabled real time quality assurance and the development of an effective and efficient manufacturing process. The identification of impurities and the development of recrystallization methods to provide active pharmaceutical ingredients (API) with optimal purity will also be addressed.

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